Rationale Challenges in drug development for psychiatric disorders have left much room for
the introduction of novel treatments with better therapeutic efficacies and indices. As a result …

Depressive disorder is the most prevalent affective disorder today. Depressive disorder has
been linked to changes in the white matter. White matter changes in depressive disorder …

Major depressive disorder (MDD), bipolar disorder (BD), and schizophrenia (SCZ) are
classified as major mental disorders and together account for the second-highest global …

Ketamine recently approved for therapy of treatment-resistant depression shows a complex
and not fully understood mechanism of action. Apart from its classical glutamatergic N …

Selective serotonin reuptakeinhibitors (SSRIs) are the gold standard treatment for major
depressive disorder (MDD). However, the use of phosphodiesterase (PDE) inhibitors in the …

Background Cilostazol, a phosphodiesterase-3 inhibitor, has been reported to improve
depressive-like behavior in experimental studies of depression. We investigated the safety …

Abstract Study Objective Paclitaxel‐induced peripheral neuropathy is a significant clinical
problem can markedly deteriorate patient's quality of life (QoL). Preclinical evidence exists …

We aimed to evaluate cilostazol therapeutic effects on aberrant behaviors of autism
spectrum disorder (ASD) children and its safety profile in a double-blind, randomized clinical …

Aim One of the most critical functions of adipose tissue is the production of adipokines, ie,
numerous active substances that regulate metabolism. One is the newly discovered …

Objective To investigate the molecular mechanism and identify potential drugs for
subthreshold depression (SD), and elucidate the detalied mechanism of Danzhi Xiaoyao …