Extracellular vesicles, from the pathogenesis to the therapy of neurodegenerative diseases

X Xia, Y Wang, JC Zheng - Translational Neurodegeneration, 2022 - Springer
Extracellular vesicles (EVs) are small bilipid layer-enclosed vesicles that can be secreted by
all tested types of brain cells. Being a key intercellular communicator, EVs have emerged as …

Internal m7G methylation: a novel epitranscriptomic contributor in brain development and diseases

X Xia, Y Wang, JC Zheng - Molecular Therapy-Nucleic Acids, 2023 - cell.com
In recent years, N7-methylguanosine (m7G) methylation, originally considered as
messenger RNA (mRNA) 5′ caps modifications, has been identified at defined internal …

Extracellular vesicles in the study of Alzheimer's and Parkinson's diseases: Methodologies applied from cells to biofluids

M Vaz, T Soares Martins… - Journal of …, 2022 - Wiley Online Library
Extracellular vesicles (EVs) are gaining increased importance in fundamental research as
key players in disease pathogenic mechanisms, but also in translational and clinical …

Exosomes in brain diseases: pathogenesis and therapeutic targets

Q Si, L Wu, D Pang, P Jiang - MedComm, 2023 - Wiley Online Library
Exosomes are extracellular vesicles with diameters of about 100 nm that are naturally
secreted by cells into body fluids. They are derived from endosomes and are wrapped in …

Potential Implications of miRNAs in the Pathogenesis, Diagnosis, and Therapeutics of Alzheimer's Disease

L Wang, X Shui, Y Diao, D Chen, Y Zhou… - International Journal of …, 2023 - mdpi.com
Alzheimer's disease (AD) is a complex multifactorial disorder that poses a substantial
burden on patients, caregivers, and society. Considering the increased aging population …

[HTML][HTML] Circulating extracellular vesicle-containing microRNAs reveal potential pathogenesis of Alzheimer's disease

Y Wang, P Yuan, L Ding, J Zhu, X Qi… - Frontiers in cellular …, 2022 - frontiersin.org
The pathogenesis of AD remains unknown till today, hindering the research and
development of AD therapeutics and diagnostics. Circulating extracellular vesicles (EVs) …

[HTML][HTML] Circulating microRNAs as diagnostic biomarkers for ischemic stroke: evidence from comprehensive analysis and real-world validation

Y Wang, X Su, GHD Leung, B Ren… - … Journal of Medical …, 2023 - ncbi.nlm.nih.gov
Ischemic stroke (IS) is the majority of strokes which remain the second leading cause of
deaths in the last two decades. Circulating microRNAs (miRNAs) have been suggested as …

Role of Exosomes in the Pathogenesis and Theranostic of Alzheimer's Disease and Parkinson's Disease

A He, M Wang, X Li, H Chen, K Lim, L Lu… - International Journal of …, 2023 - mdpi.com
Alzheimer's disease (AD) and Parkinson's disease (PD) are the most common
neurodegenerative diseases (NDDs) threatening the lives of millions of people worldwide …

[HTML][HTML] The emerging double-edged sword role of exosomes in Alzheimer's disease

T Liang, Z Wu, J Li, S Wu, W Shi… - Frontiers in Aging …, 2023 - frontiersin.org
Alzheimer's disease (AD) is the most common neurodegenerative disease characterized by
progressive loss of memory and cognitive dysfunction. The primary pathological hallmarks of …

Exosomes: potential targets for the diagnosis and treatment of neuropsychiatric disorders

H Li, Y Yuan, Q Xie, Z Dong - Journal of Translational Medicine, 2024 - Springer
The field of neuropsychiatry is considered a middle ground between neurological and
psychiatric disorders, thereby bridging the conventional boundaries between matter and …