We previously demonstrated that pancreatic stellate cells within pancreatic ductal
adenocarcinoma (PDAC) stroma secrete lumican and its presence is associated with …

Cancer evolution is a stochastic process both at the genome and gene levels. Most of
tumors contain multiple genetic subclones, evolving in either succession or in parallel, either …

Background and Purpose YC‐1 exhibits potent anticancer activity via numerous actions in
many cancer cell lines. Hence, we investigated the in vivo antitumour efficacy of YC‐1 in an …

Background MicroRNAs can be used in the prognosis of malignancies; however, their
regulatory mechanisms are unknown, especially in pancreatic ductal adenocarcinoma …

Casitas B-lineage lymphoma (CBL) is a ubiquitin ligase (E3) that becomes activated upon
Tyr371-phosphorylation and targets receptor protein tyrosine kinases for ubiquitin-mediated …

Analysis of the biological gene networks involved in a disease may lead to the identification
of therapeutic targets. Such analysis requires exploring network properties, in particular the …

Molecular targeted therapy has become an emerging promising strategy in cancer
treatment, and screening the agents targeting at cancer cell specific targets is very desirable …

Cortactin (CTTN), a cytoskeletal protein and substrate of Src kinase, is implicated in tumor
aggressiveness. However, its role in bone cell differentiation remains unknown. The current …

Growing evidence has revealed that microRNAs could regulate the proliferation of
pancreatic ductal adenocarcinoma (PDAC) cells and predict the prognosis of PDAC. Here …

The tumor-suppressing function of SMAD4 is frequently subverted during mammary
tumorigenesis, leading to cancer growth, invasion, and metastasis. A long-standing concept …