Macrophages represent a heterogeneous cell population and are known to display a
remarkable plasticity. In response to distinct micro-environmental stimuli, eg, tumor stroma …

Cytokines and chemokines are proteins that coordinate the immune response throughout
the body. The dysregulation of cytokines and chemokines is a central feature in the …

Trained immunity is a process in which innate immune cells undergo functional
reprogramming in response to pathogens or damage‐associated molecules leading to an …

Address reprint requests to Barrett J. Rollins, MD, PhD, Dana-kines than humans (for
example, there is no clear-cut murine Farber Cancer Institute, 44 Binney St, Boston, MA …

Myocardial infarction is the most common cause of cardiac injury and results in acute loss of
a large number of myocardial cells. Because the heart has negligible regenerative capacity …

Chemokines are a structurally related family of cytokines that are important for leukocyte
trafficking. The CC chemokine monocyte chemoattractant protein-1 (MCP-1) is a potent …

The pathophysiology of restenosis involves early elements of direct injury to smooth muscle
cells, deendothelialization, and thrombus deposition. Over time, this leads to smooth muscle …

Chemokines and their receptors have crucial roles in the trafficking of leukocytes, and are of
particular interest in the context of the unique immune responses elicited in the central …

Inflammatory response represents one of the first immune processes following injury. It is
characterized by the production of various molecules that initiate the recruitment of immune …

Monocyte activation and adhesion to the endothelium play important roles in inflammatory
and cardiovascular diseases. These processes are further aggravated by hyperglycemia …