Platelets represent an important linkage between inflammation, thrombosis, and
atherogenesis. Inflammation is characterized by interactions among platelets, leukocytes …

Extracellular proteolysis is an absolute requirement for new blood vessel formation
(angiogenesis). This review examines the role of the matrix metalloproteinase (MMP) and …

Once escaped from the quiescence niche, precursor cells interact with stromal components
that support their survival, proliferation, and differentiation. We examined interplays between …

The urokinase plasminogen activator (uPA) system consists of the serine protease uPA, its
glycolipid-anchored receptor, uPAR and its 2 serpin inhibitors, plasminogen activator …

Dendritic cells (DCs) are recruited from blood into tissues to patrol for foreign antigens. After
antigen uptake and processing, DCs migrate to the secondary lymphoid organs to initiate …

All forms of pulmonary hypertension are characterized by structural changes in pulmonary
arteries. Increased numbers of cells expressing α-smooth muscle (α-SM) actin is a nearly …

Colon adenocarcinomas are known to express elevated levels of α2-6 sialylation and
increased activity of ST6Gal-I, the Golgi glycosyltransferase that creates α2-6 linkages …

The function of urokinase and its receptor is essential for cell migration in pathological
conditions, as shown by the analysis of knockout mice phenotypes. How a protease of a …

Staphylococcus aureus is a human pathogen that secretes proteins that contribute to
bacterial colonization. Here we describe the extracellular adherence protein (Eap) as a …

The urokinase plasminogen activator system, which is a serine protease family include
urokinase-type plasminogen activator (uPA), the uPA receptor and plasminogen activator …