Reflections on telomere dynamics and ageing-related diseases in humans
A Aviv, JW Shay - … Transactions of the Royal Society B …, 2018 - royalsocietypublishing.org
Epidemiological studies have principally relied on measurements of telomere length (TL) in
leucocytes, which reflects TL in other somatic cells. Leucocyte TL (LTL) displays vast …
leucocytes, which reflects TL in other somatic cells. Leucocyte TL (LTL) displays vast …
Immune Activation and CD8+ T-Cell Differentiation towards Senescence in HIV-1 Infection
L Papagno, CA Spina, A Marchant, M Salio… - PLoS …, 2004 - journals.plos.org
Progress in the fight against the HIV/AIDS epidemic is hindered by our failure to elucidate
the precise reasons for the onset of immunodeficiency in HIV-1 infection. Increasing …
the precise reasons for the onset of immunodeficiency in HIV-1 infection. Increasing …
Occurrence of T cells in the brain of Alzheimer's disease and other neurological diseases
T Togo, H Akiyama, E Iseki, H Kondo, K Ikeda… - Journal of …, 2002 - Elsevier
We investigated the occurrence of T cells in the brain parenchyma of Alzheimer's disease
(AD), non-AD degenerative dementias and controls by semi-quantitative analysis of …
(AD), non-AD degenerative dementias and controls by semi-quantitative analysis of …
Longitudinal studies of clonally expanded CD8 T cells reveal a repertoire shrinkage predicting mortality and an increased number of dysfunctional cytomegalovirus …
SR Hadrup, J Strindhall, T Køllgaard… - The Journal of …, 2006 - journals.aai.org
The age-associated decrease in functionality of the human immune system is thought to
have a negative impact on the capacity to provide protection against infection, in turn …
have a negative impact on the capacity to provide protection against infection, in turn …
Primary immune responses to human CMV: a critical role for IFN-γ–producing CD4+ T cells in protection against CMV disease
LE Gamadia, EBM Remmerswaal… - Blood, The Journal …, 2003 - ashpublications.org
The correlates of protective immunity to disease-inducing viruses in humans remain to be
elucidated. We determined the kinetics and characteristics of cytomegalovirus (CMV) …
elucidated. We determined the kinetics and characteristics of cytomegalovirus (CMV) …
High Frequencies of Naive Melan-a/Mart-1–Specific Cd8+ T Cells in a Large Proportion of Human Histocompatibility Leukocyte Antigen (Hla)-A2 Individuals
Using fluorescent HLA-A* 0201 tetramers containing the immunodominant Melan-A/MART-1
(Melan-A) tumor-associated antigen (Ag), we previously observed that metastatic lymph …
(Melan-A) tumor-associated antigen (Ag), we previously observed that metastatic lymph …
An immune risk phenotype, cognitive impairment, and survival in very late life: impact of allostatic load in Swedish octogenarian and nonagenarian humans
A Wikby, F Ferguson, R Forsey… - The Journals of …, 2005 - academic.oup.com
In the previous OCTO longitudinal study, we identified an immune risk phenotype (IRP) of
high CD8 and low CD4 numbers and poor proliferative response. We also demonstrated …
high CD8 and low CD4 numbers and poor proliferative response. We also demonstrated …
Fractalkine in vascular biology: from basic research to clinical disease
H Umehara, ET Bloom, T Okazaki… - … , and vascular biology, 2004 - Am Heart Assoc
Fractalkine (now also called CX3CL1) is a unique chemokine that functions not only as a
chemoattractant but also as an adhesion molecule and is expressed on endothelial cells …
chemoattractant but also as an adhesion molecule and is expressed on endothelial cells …
Emerging role of homo-and heterodimerization in G-protein-coupled receptor biosynthesis and maturation
The idea that G-protein-coupled receptors (GPCRs) can function as dimers is now generally
accepted. Although an increasing amount of data suggests that dimers represent the basic …
accepted. Although an increasing amount of data suggests that dimers represent the basic …
Dual functions of fractalkine/CX3C ligand 1 in trafficking of perforin+/granzyme B+ cytotoxic effector lymphocytes that are defined by CX3CR1 expression
M Nishimura, H Umehara, T Nakayama… - The Journal of …, 2002 - journals.aai.org
Fractalkine/CX3C ligand 1 and its receptor CX3CR1 are known to mediate both cell
adhesion and cell migration. Here we show that CX3CR1 defines peripheral blood cytotoxic …
adhesion and cell migration. Here we show that CX3CR1 defines peripheral blood cytotoxic …