A diverse group of toxicants has been identified that cause injury to the lung including gases
(eg, ozone, chlorine), particulates/aerosols (eg, diesel exhaust, fly ash, other combustion …

Deregulation of normal regenerative responses to physical, chemical and biological toxins
in susceptible individuals leads to abnormal remodelling of extracellular matrix with …

Interstitial lung disease (ILD) comprises a large number of chronic lung disease
characterized by varying degrees of inflammation and fibrosis. Mostly they are idiopathic …

Idiopathic pulmonary fibrosis (IPF) is a progressive fibrotic lung disease where invasive
pulmonary myofibroblasts secrete collagen and destroy lung integrity. Here, we show that …

Since early times, the people of Morocco use medicinal and aromatic plants as traditional
medicine to heal different human ailments. However, little studies have been made in the …

Pirfenidone is an orally active small molecule that has recently been evaluated in large
clinical trials for the treatment of idiopathic pulmonary fibrosis, a fatal disease in which the …

Different animal models of pulmonary fibrosis have been developed to investigate potential
therapies for idiopathic pulmonary fibrosis (IPF). The most common is the bleomycin model …

Ethno-pharmacological relevance To best of our knowledge it is first quantitative ethno-
botanical study from Alpine and Sub-alpine, Western Himalaya of Pakistan. The study aims …

Pirfenidone, a broad-spectrum antifibrotic agent, is known to have efficacy in certain fibrotic
disease models, and is under clinical trials in patients with idiopathic pulmonary fibrosis. We …

Despite its disadvantages, the bleomycin animal model remains the best available
experimental tool for studying disease pathogenesis and testing of novel pharmaceutical …