Application of lipids and their potential replacers in plant-based meat analogs

Q Chen, Z Chen, J Zhang, Q Wang, Y Wang - Trends in Food Science & …, 2023 - Elsevier
Background Recently, plant-based meat analogs have attracted extensive interest due to
their contributions to environmental sustainability, animal welfare protection and health …

Surface charge changes in spike RBD mutations of SARS-CoV-2 and its variant strains alter the virus evasiveness via HSPGs: A review and mechanistic hypothesis

Z Zhang, J Zhang, J Wang - Frontiers in Public Health, 2022 - frontiersin.org
With the COVID-19 pandemic continuing, more contagious SARS-CoV-2 variants, including
Omicron, have been emerging. The mutations, especially those that occurred on the spike …

Structural evolution of SARS-CoV-2 omicron in human receptor recognition

W Zhang, K Shi, Q Geng, M Herbst, M Wang… - Journal of …, 2023 - Am Soc Microbiol
Understanding the evolutionary strategies of the SARS-CoV-2 omicron variant is crucial for
comprehending the COVID-19 pandemic and preventing future coronavirus pandemics. In …

Design and experimental validation of an optimized microalgae-bacteria consortium for the bioremediation of glyphosate in continuous photobioreactors

L Borella, G Novello, M Gasparotto, G Renella… - Journal of Hazardous …, 2023 - Elsevier
Glyphosate will be banned from Europe by the end of 2022, but its widespread use in the
last decades and its persistence in the environment require the development of novel …

Self-supervised pocket pretraining via protein fragment-surroundings alignment

B Gao, Y Jia, Y Mo, Y Ni, W Ma, Z Ma, Y Lan - arXiv preprint arXiv …, 2023 - arxiv.org
Pocket representations play a vital role in various biomedical applications, such as
druggability estimation, ligand affinity prediction, and de novo drug design. While existing …

Investigation of the MDM2-binding potential of de novo designed peptides using enhanced sampling simulations

OA Durojaye, AA Yekeen, MO Idris, NO Okoro… - International Journal of …, 2024 - Elsevier
The tumor suppressor p53 plays a crucial role in cellular responses to various stresses,
regulating key processes such as apoptosis, senescence, and DNA repair. Dysfunctional …

Comparative molecular dynamics study of the receptor-binding domains in SARS-CoV-2 and SARS-CoV and the effects of mutations on the binding affinity

S Rezaei, Y Sefidbakht, V Uskoković - Journal of Biomolecular …, 2022 - Taylor & Francis
Here, we report on a computational comparison of the receptor-binding domains (RBDs) on
the spike proteins of severe respiratory syndrome coronavirus‐2 (SARS-CoV-2) and SARS …

Electrostatic complementarity at the interface drives transient protein-protein interactions

G Grassmann, L Di Rienzo, G Gosti, M Leonetti… - Scientific Reports, 2023 - nature.com
Understanding the mechanisms driving bio-molecules binding and determining the resulting
complexes' stability is fundamental for the prediction of binding regions, which is the starting …

Nanobodies targeting LexA autocleavage disclose a novel suppression strategy of SOS-response pathway

L Maso, F Vascon, M Chinellato, F Goormaghtigh… - Structure, 2022 - cell.com
Antimicrobial resistance threatens the eradication of infectious diseases and impairs the
efficacy of available therapeutics. The bacterial SOS pathway is a conserved response …

Physicochemical impact of bioactive terpenes on the microalgae biomass structural characteristics

M Gouda, Z Huang, Y Liu, Y He, X Li - Bioresource technology, 2021 - Elsevier
This study aimed to evaluate the functionality of bioactive terpenes on Spirulina (Arthrospira
platensis; AP) and Chlorella (Chlorella vulgaris; CV) biomasses. The two microalgae …