Current understanding of conventional outflow dysfunction in glaucoma

WD Stamer, TS Acott - Current opinion in ophthalmology, 2012 - journals.lww.com
Current understanding of conventional outflow dysfunction in... : Current Opinion in
Ophthalmology Current understanding of conventional outflow dysfunction in glaucoma …

Role of the Rho GTPase/Rho kinase signaling pathway in pathogenesis and treatment of glaucoma: Bench to bedside research

PV Rao, PP Pattabiraman, C Kopczynski - Experimental eye research, 2017 - Elsevier
Glaucoma is a leading cause of irreversible blindness worldwide. Elevated intraocular
pressure (IOP) is considered to be a predominant risk factor for primary open angle …

The endocannabinoid system as a therapeutic target in glaucoma

EA Cairns, WH Baldridge, MEM Kelly - Neural plasticity, 2016 - Wiley Online Library
Glaucoma is an irreversible blinding eye disease which produces progressive retinal
ganglion cell (RGC) loss. Intraocular pressure (IOP) is currently the only modifiable risk …

Adenosine, adenosine receptors and glaucoma: an updated overview

Y Zhong, Z Yang, WC Huang, X Luo - Biochimica et Biophysica Acta (BBA) …, 2013 - Elsevier
BACKGROUND: Glaucoma, a leading cause of blindness worldwide, is an optic neuropathy
commonly associated with elevated intraocular pressure (IOP). The major goals of glaucoma …

Effect of prostaglandin analogues on tear proteomics and expression of cytokines and matrix metalloproteinases in the conjunctiva and cornea

HYL Park, JH Kim, KM Lee, CK Park - Experimental eye research, 2012 - Elsevier
The purpose of this work was to identify potential tear-film-based proteins and their effect on
changes in the conjunctiva and cornea in eyes using prostaglandin (PG) analogues …

[HTML][HTML] Autotaxin-lysophosphatidic acid axis is a novel molecular target for lowering intraocular pressure

P Iyer, R Lalane III, C Morris, P Challa, R Vann, PV Rao - 2012 - journals.plos.org
Primary open-angle glaucoma is the second leading cause of blindness in the United States
and is commonly associated with elevated intraocular pressure (IOP) resulting from …

Melatonin receptors trigger cAMP production and inhibit chloride movements in nonpigmented ciliary epithelial cells

F Huete-Toral, A Crooke, A Martínez-Águila… - Journal of Pharmacology …, 2015 - ASPET
Melatonin and its analog 5-MCA-NAT (5-methylcarboxyamino-N-acetyl tryptamine) are
active compounds reducing intraocular pressure (IOP). This action is mediated through MT2 …

[HTML][HTML] Suppl 1: M5: Present and new treatment strategies in the management of glaucoma

M Kolko - The open ophthalmology journal, 2015 - ncbi.nlm.nih.gov
Glaucoma is a neurodegenerative disease characterized by retinal ganglion cell (RGC)
death and axonal loss. It remains a major cause of blindness worldwide. All current …

[HTML][HTML] RhoA GTPase-induced ocular hypertension in a rodent model is associated with increased fibrogenic activity in the trabecular meshwork

PP Pattabiraman, T Rinkoski, E Poeschla… - The American journal of …, 2015 - Elsevier
Ocular hypertension arising from increased resistance to aqueous humor (AH) outflow
through the trabecular meshwork is a primary risk factor for open-angle glaucoma, a leading …

[HTML][HTML] TGF-β-induced IOP elevations are mediated by RhoA in the early but not the late fibrotic phase of open angle glaucoma

LJ Hill, B Mead, CN Thomas, S Foale, E Feinstein… - Molecular …, 2018 - ncbi.nlm.nih.gov
Purpose Elevations in intraocular pressure (IOP) are associated with the development of
glaucoma and loss of sight. High transforming growth factor-β (TGF-β) 1 levels in the eye's …