[HTML][HTML] Omega-3 fatty acids and individual variability in plasma triglyceride response: A mini-review

A Rundblad, V Sandoval, KB Holven, JM Ordovás… - Redox Biology, 2023 - Elsevier
Cardiovascular disease (CVD) is a leading cause of death worldwide. Supplementation with
the marine omega-3 fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid …

Nrf2-mediated therapeutic effects of dietary flavones in different diseases

W Huang, Y Zhong, B Gao, B Zheng… - Frontiers in Pharmacology, 2023 - frontiersin.org
Oxidative stress (OS) is a pathological status that occurs when the body's balance between
oxidants and antioxidant defense systems is broken, which can promote the development of …

BACH1 promotes tissue necrosis and Mycobacterium tuberculosis susceptibility

EP Amaral, S Namasivayam, ATL Queiroz… - Nature …, 2024 - nature.com
Oxidative stress triggers ferroptosis, a form of cellular necrosis characterized by iron-
dependent lipid peroxidation, and has been implicated in Mycobacterium tuberculosis (Mtb) …

Endogenous production of ω-3 polyunsaturated fatty acids mitigates cisplatin-induced myelosuppression by regulating NRF2-MDM2-p53 signaling pathway

Q Xu, Z Zhang, M Tang, C Xing, H Chen… - Free Radical Biology …, 2023 - Elsevier
Cisplatin is a chemotherapy medication used to treat a wide range of cancers. A common
side effect of cisplatin is myelosuppression. Research suggests that oxidative damages are …

Vitamin D, calbindin, and calcium signaling: unraveling the Alzheimer's connection

M Acharya, N Singh, G Gupta, MM Tambuwala… - Cellular signalling, 2024 - Elsevier
Calcium is a ubiquitous second messenger that is indispensable in regulating
neurotransmission and memory formation. A precise intracellular calcium level is achieved …

Dietary Astaxanthin: a promising antioxidant and anti-inflammatory agent for brain aging and adult neurogenesis

A Medoro, S Davinelli, L Milella, BJ Willcox, RC Allsopp… - Marine Drugs, 2023 - mdpi.com
Decreased adult neurogenesis, or the gradual depletion of neural stem cells in adult
neurogenic niches, is considered a hallmark of brain aging. This review provides a …

NRF2 signaling pathway and telomere length in aging and age-related diseases

A Medoro, L Saso, G Scapagnini, S Davinelli - Molecular and Cellular …, 2023 - Springer
The transcription factor nuclear factor erythroid 2-related factor 2 (NRF2) is well recognized
as a critical regulator of redox, metabolic, and protein homeostasis, as well as the regulation …

PROTACs: A novel strategy for cancer drug discovery and development

X Han, Y Sun - MedComm, 2023 - Wiley Online Library
Proteolysis targeting chimera (PROTAC) technology has become a powerful strategy in drug
discovery, especially for undruggable targets/proteins. A typical PROTAC degrader consists …

[HTML][HTML] Nutraceuticals as modulators of immune function: a review of potential therapeutic effects

A Medoro, S Davinelli, A Colletti… - … Nutrition and Food …, 2023 - ncbi.nlm.nih.gov
Dietary supplementation with nutraceuticals can promote optimal immune system activation,
modulating different pathways that enhance immune defenses. Therefore, the immunity …

The Potential Role of Major Argan Oil Compounds as Nrf2 Regulators and Their Antioxidant Effects

R El Kebbaj, H Bouchab, M Tahri-Joutey, S Rabbaa… - Antioxidants, 2024 - mdpi.com
In recent years, research on the discovery of natural compounds with potent antioxidant
properties has resulted in growing interest in these compounds due to their potential …