Over 65% of people with obesity display the metabolic-associated fatty liver disease
(MAFLD), which can manifest as steatohepatitis, fibrosis, cirrhosis, or liver cancer. The …

Insulin resistance is an important feature of metabolic syndrome and a precursor of type 2
diabetes mellitus (T2DM). Overnutrition-induced obesity is a major risk factor for the …

There is considerable heterogeneity in the cardiometabolic abnormalities associated with
obesity. We evaluated multi-organ system metabolic function in 20 adults with metabolically …

The liver is central in regulating glucose homeostasis, being the major contributor to
endogenous glucose production and the greatest reserve of glucose as glycogen. It is both a …

OBJECTIVE Diabetes may feature impaired insulin kinetics, which could be aggravated by
altered hepatic metabolism and glycemic control. Thus, we examined insulin clearance and …

A large number of populations are living with diabetes, which is the most common endocrine
disorder which is classified into Type-I and Type-II diabetes. Diabetes is one of the listed …

Insulin resistance (IR) and the associated hyperinsulinemia are early pathophysiological
changes which, if not well treated, can lead to type 2 diabetes, endothelial dysfunction and …

Metabolic tests are vital to determine in vivo insulin sensitivity and glucose metabolism in
preclinical models, usually rodents. Such tests include glucose tolerance tests, insulin …

Insulin receptor (IR) controls growth and metabolism. Insulin-like growth factor 2 (IGF2) has
different binding properties on two IR isoforms, mimicking insulin's function. However, the …

Metabolic dysfunction-associated steatotic liver disease (MASLD) is closely associated with
other features of the metabolic syndrome such as type 2 diabetes. The progression of the …