New developments in the biology of fibroblast growth factors
DM Ornitz, N Itoh - WIREs mechanisms of disease, 2022 - Wiley Online Library
The fibroblast growth factor (FGF) family is composed of 18 secreted signaling proteins
consisting of canonical FGFs and endocrine FGFs that activate four receptor tyrosine …
consisting of canonical FGFs and endocrine FGFs that activate four receptor tyrosine …
Negative regulation of FGFR (fibroblast growth factor receptor) signaling
P Szybowska, M Kostas, J Wesche, EM Haugsten… - Cells, 2021 - mdpi.com
FGFR (fibroblast growth factor receptor) signaling controls fundamental processes in
embryonic, fetal and adult human life. The magnitude, duration, and location of FGFR …
embryonic, fetal and adult human life. The magnitude, duration, and location of FGFR …
Targeting cellular trafficking of fibroblast growth factor receptors as a strategy for selective cancer treatment
N Porębska, M Latko, M Kucińska… - Journal of clinical …, 2018 - mdpi.com
Fibroblast growth factor receptors (FGFRs) in response to fibroblast growth factors (FGFs)
transmit signals across the cell membrane, regulating important cellular processes, like …
transmit signals across the cell membrane, regulating important cellular processes, like …
Protein tyrosine phosphatase receptor type G (PTPRG) controls fibroblast growth factor receptor (FGFR) 1 activity and influences sensitivity to FGFR kinase inhibitors
M Kostas, EM Haugsten, Y Zhen, V Sørensen… - Molecular & Cellular …, 2018 - ASBMB
Recently, FGFR1 was found to be overexpressed in osteosarcoma and represents an
important target for precision medicine. However, because targeted cancer therapy based …
important target for precision medicine. However, because targeted cancer therapy based …
Nuclear receptor tyrosine kinase transport and functions in cancer
Signaling functions of plasma membrane-localized receptor tyrosine kinases (RTKs) have
been extensively studied after they were first described in the mid-1980s. Plasma membrane …
been extensively studied after they were first described in the mid-1980s. Plasma membrane …
Antibody-induced dimerization of FGFR1 promotes receptor endocytosis independently of its kinase activity
Ł Opaliński, A Sokołowska-Wędzina, M Szczepara… - Scientific Reports, 2017 - nature.com
Fibroblast growth factors (FGFs) and their plasma membrane-localized receptors (FGFRs)
play a key role in the regulation of developmental processes and metabolism. Aberrant …
play a key role in the regulation of developmental processes and metabolism. Aberrant …
Proximity Labeling by a recombinant APEX2–FGF1 fusion protein reveals interaction of FGF1 with the proteoglycans CD44 and CSPG4
Fibroblast growth factor 1 (FGF1) binds to specific FGF receptors (FGFRs) at the surface of
target cells to initiate intracellular signaling. While heparan sulfate proteoglycans (HSPGs) …
target cells to initiate intracellular signaling. While heparan sulfate proteoglycans (HSPGs) …
Glycosylation of FGFR4 in cholangiocarcinoma regulates receptor processing and cancer signaling
Recent advances in targeted treatment for cholangiocarcinoma have focused on fibroblast
growth factor (FGF) signaling. There are four receptor tyrosine kinases that respond to FGFs …
growth factor (FGF) signaling. There are four receptor tyrosine kinases that respond to FGFs …
Imaging the fibroblast growth factor receptor network on the plasma membrane with DNA-assisted single-molecule super-resolution microscopy
MS Schröder, MLIE Harwardt, JV Rahm, Y Li, P Freund… - Methods, 2021 - Elsevier
Fibroblast growth factor receptors (FGFRs) are a subfamily of receptor tyrosine kinases and
central players in health and disease. Following ligand binding and the formation of homo …
central players in health and disease. Following ligand binding and the formation of homo …
Analysis of K-Ras interactions by biotin ligase tagging
Background: Mutations of the human K-Ras 4B (K-Ras) G protein are associated with a
significant proportion of all human cancers. Despite this fact, a comprehensive analysis of K …
significant proportion of all human cancers. Despite this fact, a comprehensive analysis of K …