Cancer DNA vaccines: current preclinical and clinical developments and future perspectives

A Lopes, G Vandermeulen, V Préat - Journal of Experimental & Clinical …, 2019 - Springer
The recent developments in immuno-oncology have opened an unprecedented avenue for
the emergence of vaccine strategies. Therapeutic DNA cancer vaccines are now considered …

Progress in the clinical detection of heterogeneity in breast cancer

JL Song, C Chen, JP Yuan, SR Sun - Cancer medicine, 2016 - Wiley Online Library
Breast cancer is currently the most common form of cancer and the second‐leading cause of
death from cancer in women. Though considerable progress has been made in the …

Endothelial cells require functional FLVCR1a during developmental and adult angiogenesis

S Petrillo, F De Giorgio, F Bertino, F Garello, V Bitonto… - Angiogenesis, 2023 - Springer
Abstract The Feline Leukemia Virus Subgroup C Receptor 1a (FLVCR1a) is a
transmembrane heme exporter essential for embryonic vascular development. However, the …

[HTML][HTML] A quantitative MRI-based approach to estimate the permeation and retention of nanomedicines in tumors

A Nomani, S Yousefi, D Sargsyan, A Hatefi - Journal of Controlled Release, 2024 - Elsevier
Despite the potential of the enhanced permeability and retention (EPR) effect in tumor
passive targeting, many nanotherapeutics have failed to produce meaningful clinical …

Evidence for the role of intracellular water lifetime as a tumour biomarker obtained by in vivo field‐cycling relaxometry

MR Ruggiero, S Baroni, S Pezzana… - Angewandte …, 2018 - Wiley Online Library
It was established through in vivo T1 measurements at low magnetic fields that tumour cells
display proton T1 values that are markedly longer than those shown by healthy tissue …

Multiparametric analysis of longitudinal quantitative MRI data to identify distinct tumor habitats in preclinical models of breast cancer

AK Syed, JG Whisenant, SL Barnes, AG Sorace… - Cancers, 2020 - mdpi.com
This study identifies physiological tumor habitats from quantitative magnetic resonance
imaging (MRI) data and evaluates their alterations in response to therapy. Two models of …

Melanin-based contrast agents for biomedical optoacoustic imaging and theranostic applications

DL Longo, R Stefania, S Aime, A Oraevsky - International journal of …, 2017 - mdpi.com
Optoacoustic imaging emerged in early 1990s as a new biomedical imaging technology that
generates images by illuminating tissues with short laser pulses and detecting resulting …

[HTML][HTML] Dual inhibition of PFKFB3 and VEGF normalizes tumor vasculature, reduces lactate production, and improves chemotherapy in glioblastoma: insights from …

J Zhang, W Xue, K Xu, L Yi, Y Guo, T Xie, H Tong… - Theranostics, 2020 - ncbi.nlm.nih.gov
Rationale: Tumor vascular normalization (TVN) is emerging to enhance the efficacy of
anticancer treatment in many cancers including glioblastoma (GBM). However, a common …

Cancer metabolism and tumor heterogeneity: imaging perspectives using MR imaging and spectroscopy

G Lin, KR Keshari, JM Park - Contrast Media & Molecular …, 2017 - Wiley Online Library
Cancer cells reprogram their metabolism to maintain viability via genetic mutations and
epigenetic alterations, expressing overall dynamic heterogeneity. The complex relaxation …

Cabozantinib exhibits potent antitumor activity in colorectal cancer patient-derived tumor xenograft models via autophagy and signaling mechanisms

AJ Scott, JJ Arcaroli, SM Bagby, R Yahn… - Molecular cancer …, 2018 - AACR
Antiangiogenic therapy used in treatment of metastatic colorectal cancer (mCRC) inevitably
succumbs to treatment resistance. Upregulation of MET may play an essential role to …