Quantitative systems pharmacology for neuroscience drug discovery and development: current status, opportunities, and challenges

H Geerts, J Wikswo, PH van der Graaf… - CPT …, 2020 - Wiley Online Library
The substantial progress made in the basic sciences of the brain has yet to be adequately
translated to successful clinical therapeutics to treat central nervous system (CNS) diseases …

Prediction of quality markers of traditional Chinese medicines based on network pharmacology

Y Wang, T Cui, Y Li, M Liao, H Zhang, W Hou… - Chinese Herbal …, 2019 - Elsevier
Network pharmacology is a powerful tool to reflect the pharmacologically active effects,
mechanism of action and toxic activity of traditional Chinese medicines (TCMs). The …

Network pharmacology study on the active components of Pterocypsela elata and the mechanism of their effect against cerebral ischemia

B Niu, H Zhang, C Li, F Yan, Y Song, G Hai… - Drug design …, 2019 - Taylor & Francis
Objective The aim of this study was to identify the active anti-ischemic components of
Pterocypsela elata (P. elata) using a network pharmacology approach to construct an …

Administration of Momordica charantia Enhances the Neuroprotection and Reduces the Side Effects of LiCl in the Treatment of Alzheimer's Disease

HJ Huang, SL Chen, YT Chang, JH Chyuan… - Nutrients, 2018 - mdpi.com
Recently, the use of natural food supplements to reduce the side effects of chemical
compounds used for the treatment of various diseases has become popular. Lithium …

Network pharmacology‐based prediction of the active ingredients, potential targets, and signaling pathways in compound Lian‐Ge granules for treatment of diabetes

J Xue, Y Shi, C Li, H Song - Journal of Cellular Biochemistry, 2019 - Wiley Online Library
Abstract Aims Compound Lian‐Ge granules (CLGGs) is a traditional Chinese medicine
preparation with good hypoglycemic effect and health function. This study was to predict its …

[HTML][HTML] Opportunities for multiscale computational modelling of serotonergic drug effects in Alzheimer's disease

A Joshi, DH Wang, S Watterson, PL McClean… - …, 2020 - Elsevier
Alzheimer's disease (AD) is an age-specific neurodegenerative disease that compromises
cognitive functioning and impacts the quality of life of an individual. Pathologically, AD is …

Hydrophilic polymer driven crystallization self-assembly: an inflammatory multi-drug combination nanosystem against Alzheimer's disease

H Hu, J Wang, J Ren, X Li, B Zhang, Z Lv… - Journal of Materials …, 2021 - pubs.rsc.org
The hydrophobic polymer driven crystallization of self-assembled micelles is usually
sufficient for their purposes in materials chemistry studies. However, with the state of smart …

Dreaming of a new world where Alzheimer's is a treatable disorder

M Catania, G Giaccone, M Salmona… - Frontiers in aging …, 2019 - frontiersin.org
Alzheimer's disease (AD) is the most common form of dementia. It'sa chronic and
untreatable neurodegenerative disease with irreversible progression and has important …

Computational modeling of cytokine signaling in microglia

WD Anderson, HK Makadia, AD Greenhalgh… - Molecular …, 2015 - pubs.rsc.org
Neuroinflammation due to glial activation has been linked to many CNS diseases. We
developed a computational model of a microglial cytokine interaction network to study the …

In silico-based screen synergistic drug combinations from herb medicines: a case using Cistanche tubulosa

J Liu, J Zhu, J Xue, Z Qin, F Shen, J Liu, X Chen, X Li… - Scientific Reports, 2017 - nature.com
Neuroinflammation is characterized by the elaborated inflammatory response repertoire of
central nervous system tissue. The limitations of the current treatments for …