Vinpocetine (VPN) is an ethyl apovincaminate that has anti-inflammatory and antioxidant
effects by inhibiting the expression of nuclear factor kappa B (NF-κB) and …

NLR family pyrin domain containing 3 (NLRP3) is expressed in immune cells, especially in
dendritic cells and macrophages and acts as a constituent of the inflammasome. This protein …

Vinpocetine (VPN) is an alkaloid derivative of vincamine inhibits phosphodiesterase type 1
that increase cyclic guanosine monophosphate and cyclic adenosine monophosphate. VPN …

Abstract β2-Microglobulin (β2M), a component of the major histocompatibility complex class
I molecule, is associated with aging-related cognitive impairment and Alzheimer's disease …

Ischemic stroke is a leading cause of death and long-term disability worldwide. The aim of
this study is to explore the potential function of ephedrine in ischemic stroke and the …

Psoriasis is an uncontrolled, long-lasting inflammatory dermatosis distinguished by
thickened, erythematous, and flaky skin lesions. Massive amounts of inflammatory cytokines …

Ischemic stroke is the primary reason for human disability and death, but the available
treatment options are limited. Hence, it is imperative to explore novel and efficient therapies …

Background Inflammasome activation is known to be involved in nonalcoholic
steatohepatitis (NASH). Vinpocetine is a derivative of vincamine and is reported to suppress …

Ischemic stroke poses a major threat to human health. Therefore, the molecular mechanisms
of cerebral ischemia/reperfusion injury (CIRI) need to be further clarified, and the associated …

Traumatic brain damage is common worldwide and the treatments are not well-defined.
Vinpocetine is a synthetic derivative of the vinca alkaloid vincamine and is clinically being …