Sepsis: mechanisms of bacterial injury to the patient

H Minasyan - Scandinavian journal of trauma, resuscitation and …, 2019 - Springer
In bacteremia the majority of bacterial species are killed by oxidation on the surface of
erythrocytes and digested by local phagocytes in the liver and the spleen. Sepsis-causing …

Developing recombinant antibodies by phage display against infectious diseases and toxins for diagnostics and therapy

KDR Roth, EV Wenzel, M Ruschig, S Steinke… - Frontiers in cellular …, 2021 - frontiersin.org
Antibodies are essential molecules for diagnosis and treatment of diseases caused by
pathogens and their toxins. Antibodies were integrated in our medical repertoire against …

Superantigenic character of an insert unique to SARS-CoV-2 spike supported by skewed TCR repertoire in patients with hyperinflammation

MH Cheng, S Zhang, RA Porritt… - Proceedings of the …, 2020 - National Acad Sciences
Multisystem Inflammatory Syndrome in Children (MIS-C) associated with COVID-19 is a
newly recognized condition in children with recent severe acute respiratory syndrome …

Staphylococcal superantigens: pyrogenic toxins induce toxic shock

T Krakauer - Toxins, 2019 - mdpi.com
Staphylococcal enterotoxin B (SEB) and related superantigenic toxins produced by
Staphylococcus aureus are potent activators of the immune system. These protein toxins …

Virulence factor targeting of the bacterial pathogen Staphylococcus aureus for vaccine and therapeutics

TL Kane, KE Carothers, SW Lee - Current drug targets, 2018 - ingentaconnect.com
Background: Staphylococcus aureus is a major bacterial pathogen capable of causing a
range of infections in humans from gastrointestinal disease, skin and soft tissue infections, to …

[HTML][HTML] An insertion unique to SARS-CoV-2 exhibits superantigenic character strengthened by recent mutations

MH Cheng, S Zhang, RA Porritt, M Arditi, I Bahar - BioRxiv, 2020 - ncbi.nlm.nih.gov
Abstract Multisystem Inflammatory Syndrome in Children (MIS-C) associated with
Coronavirus Disease 2019 (COVID-19) is a newly recognized condition in which children …

Understanding mechanisms of virulence in MRSA: implications for antivirulence treatment strategies

RC Hsieh, R Liu, DJ Burgin, M Otto - Expert Review of Anti-infective …, 2023 - Taylor & Francis
ABSTRACT Introduction Methicillin-resistant Staphylococcus aureus (MRSA) is a
widespread pathogen, often causing recurrent and deadly infections in the hospital and …

Investigational drugs to treat methicillin-resistant Staphylococcus aureus

C Vuong, AJ Yeh, GYC Cheung… - Expert opinion on …, 2016 - Taylor & Francis
Introduction: Staphylococcus aureus remains one of the leading causes of morbidity and
mortality worldwide. This is to a large extent due to antibiotic-resistant strains, in particular …

Recombinant antibodies for diagnostics and therapy against pathogens and toxins generated by phage display

P Kuhn, V Fühner, T Unkauf… - Proteomics–Clinical …, 2016 - Wiley Online Library
Antibodies are valuable molecules for the diagnostic and treatment of diseases caused by
pathogens and toxins. Traditionally, these antibodies are generated by hybridoma …

Review of the inhibition of biological activities of food-related selected toxins by natural compounds

M Friedman, R Rasooly - Toxins, 2013 - mdpi.com
There is a need to develop food-compatible conditions to alter the structures of fungal,
bacterial, and plant toxins, thus transforming toxins to nontoxic molecules. The term …