Metformin contamination in global waters: Biotic and abiotic transformation, byproduct generation and toxicity, and evaluation as a pharmaceutical indicator

Y He, Y Zhang, F Ju - Environmental Science & Technology, 2022 - ACS Publications
Metformin is the first-line antidiabetic drug and one of the most prescribed medications
worldwide. Because of its ubiquitous occurrence in global waters and demonstrated …

Metformin as an emerging concern in wastewater: Occurrence, analysis and treatment methods

A Balakrishnan, M Sillanpää, MM Jacob… - Environmental Research, 2022 - Elsevier
Metformin is a wonder drug used as an anti-hypoglycemic medication; it is also used as a
cancer suppression medicament. Metformin is a first line of drug choice used by doctors for …

Aerobic Degradation of the Antidiabetic Drug Metformin by Aminobacter sp. Strain NyZ550

T Li, ZJ Xu, NY Zhou - Environmental Science & Technology, 2023 - ACS Publications
Metformin is becoming one of the most common emerging contaminants in surface and
wastewater. Its biodegradation generally leads to the accumulation of guanylurea in the …

[HTML][HTML] The role of AMPK-dependent pathways in cellular and molecular mechanisms of metformin: a new perspective for treatment and prevention of diseases

A Hasanvand - Inflammopharmacology, 2022 - Springer
Metformin can suppress gluconeogenesis and reduce blood sugar by activating adenosine
monophosphate-activated protein kinase (AMPK) and inducing small heterodimer partner …

Adverse effects of perfluoroalkyl acids on fish and other aquatic organisms: A review

JW Lee, K Choi, K Park, C Seong, S Do Yu… - Science of the Total …, 2020 - Elsevier
Perfluoroalkyl acids (PFAAs) have been widely used in many industrial and consumer
products. They have been detected ubiquitously in ambient water along with other …

Metformin environmental exposure: A systematic review

EP Ambrosio-Albuquerque, LF Cusioli… - Environmental …, 2021 - Elsevier
This review discussed the occurrence, ecological impacts, and effects of metformin, a drug
used for type 2 diabetes among other diseases. It is one of the most commonly found …

Antidiabetic drug metformin disrupts the embryogenesis in zebrafish through an oxidative stress mechanism

GA Elizalde-Velázquez, LM Gómez-Oliván… - Chemosphere, 2021 - Elsevier
In recent years, the consumption of metformin has increased not only due to the higher
prevalence of type 2 diabetes, but also due to their usage for other indications such as …

Occurrence, toxic effects and removal of metformin in the aquatic environments in the world: Recent trends and perspectives

GA Elizalde-Velázquez, LM Gómez-Oliván - Science of The Total …, 2020 - Elsevier
Metformin (MET) is the most common drug used to treat type 2 diabetes, but also it is used
as an anticancer agent and as a treatment for polycystic ovary syndrome. This drug is not …

Promoted removal of metformin hydrochloride anti-diabetic drug from water by fabricated and modified nanobiochar from artichoke leaves

ME Mahmoud, AM El-Ghanam, SR Saad… - Sustainable Chemistry …, 2020 - Elsevier
Biochars are economic and ecofriendly biosorbents normally prepared from different
agricultural or animal wastes with some functional groups that afford strong capability for …

Health impact assessment after Danio rerio long-term exposure to environmentally relevant concentrations of metformin and guanylurea

GA Elizalde-Velázquez, SE Herrera-Vázquez… - Chemosphere, 2023 - Elsevier
The antidiabetic drug metformin (MET) and its metabolite guanylurea (GUA) have been
frequently and ubiquitously detected in surface water. Consequently, there has been a …