Large-scale genome-wide association studies conducted over the last decade have
uncovered numerous genetic variants associated with cardiometabolic traits and risk factors …

Blood pressure is regulated by a complex neurohumoral system including the renin-
angiotensin-aldosterone system, natriuretic peptides, endothelial pathways, the sympathetic …

Background: Hypertension or elevated blood pressure (BP) is an important risk factor for
aortic dissection (AD); however, few prospective studies on this topic have been published …

Aims Several observational studies have investigated the association between hypertension
or elevated systolic blood pressure and diastolic blood pressure and risk of heart failure, but …

Aims Elevated blood pressure (BP) is a prevalent modifiable risk factor for cardiovascular
diseases and contributes to cognitive decline in late life. Despite the fact that functional …

A true discrepancy between the effect of systolic blood pressure (SBP) and diastolic blood
pressure (DBP) on cardiovascular (CV) outcomes remains unclear. This study performed …

Hypertension (HT) is a modifiable risk factor for life-threatening cardiovascular diseases
(CVDs) including coronary artery disease, heart failure, or stroke. Despite significant …

Introduction In observational studies, venous thromboembolism (VTE) has been associated
with Cushing's syndrome and with persistent mental stress, two conditions associated with …

Scientifically interesting as well as practically important phenotypes often belong to the
realm of complex traits. To the extent that these traits are hereditary, they are usually 'highly …

BACKGROUND Mendelian randomization (MR) offers a powerful approach to study
potential causal associations between exposures and health outcomes by using genetic …