Flavonoids are a group of natural polyphenol substances abundant in vegetables, fruits,
grains, and tea. As plant secondary metabolites, flavonoids play essential roles in many …

The endothelium, a cellular monolayer lining the blood vessel wall, plays a critical role in
maintaining multiorgan health and homeostasis. Endothelial functions in health include …

Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is the virus responsible
for the COVID-19 pandemic. Patients may present as asymptomatic or demonstrate mild to …

Calcific aortic valve disease (CAVD) is the end result of active cellular processes that lead to
the progressive fibrosis and calcification of aortic valve leaflets. In western populations …

Among all physiologic functions of nitric oxide (NO) known so far, NO-dependent regulation
of vascular tone is one of the most important. Under physiological conditions vascular NO is …

Severe acute respiratory syndrome coronavirus (SARS-CoV-2) infection is a recent
pandemic infectious disease caused by severe acute respiratory syndrome coronavirus …

Global plastic use has increased rapidly, and environmental pollution associated with
nanoplastics (NPs) has been a growing concern recently. However, the impact and …

Objective To synthesize more conclusive evidence on the anti-inflammatory effects of
angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers …

The recently described severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has
infected millions of people, with thousands of fatalities. It has prompted global efforts in …

Angiotensin-converting enzyme inhibitors are widely used for treatment of hypertension and
related diseases. Here, six karnamicins E1-E6 (1–6), which bear fully substituted …