Answer questions and earn CME/CNE Pancreatic cancer is currently one of the deadliest of
the solid malignancies. However, surgery to resect neoplasms of the pancreas is safer and …

Pancreatic ductal adenocarcinoma is a devastating disease, and patient outcomes have not
improved in decades. Treatments that target tumor cells have largely failed. This could be …

The local extension of cancer cells along nerves is a frequent clinical finding for various
tumours. Traditionally, nerve invasion was assumed to occur via the path of least resistance; …

Nerves are important pathological elements of the microenvironment of tumors, including
those in pancreatic, colon and rectal, prostate, head and neck, and breast cancers. Recent …

Studies have reported the vital role of nerves in tumorigenesis and cancer progression.
Nerves infiltrate the tumor microenvironment thereby enhancing cancer growth and …

Pancreatic ductal adenocarcinoma (PDAC) and cholangiocarcinoma (CCA) are both deadly
cancers and they share many biological features besides their close anatomical location …

Background & Aims Little is known about mechanisms of perineural invasion (PNI) by
pancreatic ductal adenocarcinomas (PDAs) or other tumors. Annexin A2 (ANXA2) regulates …

Pancreatic ductal adenocarcinoma (PDAC) is an aggressive malignant disease with a
unique tumor microenvironment surrounded by an interlaced network of cancer and …

The remarkable aggressiveness of pancreatic cancer has never been fully explained.
Although clearly multifactorial, we postulate that venous invasion, a finding seen in most …

Background The purpose of this study was to evaluate a single-institution experience with
delivery of preoperative therapy to patients with pancreatic ductal adenocarcinoma (PDAC) …