Stem cell niches are specialized microenvironments that promote the maintenance of stem
cells and regulate their function. Recent advances have improved our understanding of the …

Liver sinusoidal endothelial cells (LSECs) are highly specialized endothelial cells
representing the interface between blood cells on the one side and hepatocytes and hepatic …

The ontogeny of human haematopoietic stem cells (HSCs) is poorly defined owing to the
inability to identify HSCs as they emerge and mature at different haematopoietic sites. Here …

Tissue-resident macrophages have pivotal functions for tissue defense and homeostasis.
Two main discoveries have changed our current understanding of macrophage …

Evidence of the diversity and multi-layered organization of the hematopoietic system is
leading to new insights that may inform ex vivo production of blood cells. Interestingly, not all …

The mammalian skeletal system harbours a hierarchical system of mesenchymal stem cells,
osteoprogenitors and osteoblasts sustaining lifelong bone formation. Osteogenesis is …

Hematopoiesis occurs in distinct waves." Definitive" hematopoietic stem cells (HSCs) with
the potential for all blood lineages emerge in the aorta-gonado-mesonephros, while" …

Rationale: Atherosclerosis is a widespread and devastating disease, but the origins of cells
within atherosclerotic plaques are not well defined. Objective: To investigate the specific …

Haematopoietic stem cells (HSCs) are derived early from embryonic precursors, such as
haemogenic endothelial cells and pre-haematopoietic stem cells (pre-HSCs), the molecular …

ABSTRACT RUNX transcription factors orchestrate many different aspects of biology,
including basic cellular and developmental processes, stem cell biology and tumorigenesis …