Calcitonin gene‐related peptide (CGRP) is a key molecule released in acute migraine attacks—Successful translation of basic science to clinical practice

L Edvinsson - Journal of Internal Medicine, 2022 - Wiley Online Library
Migraine is a highly prevalent neurovascular disorder afflicting more than 15% of the global
population. Nearly three times more females are afflicted by migraine in the 18–50 years …

Could experimental inflammation provide better understanding of migraines?

PV Reducha, L Edvinsson, KA Haanes - Cells, 2022 - mdpi.com
Migraines constitute a common neurological and headache disorder affecting around 15%
of the world's population. In addition to other mechanisms, neurogenic neuroinflammation …

[HTML][HTML] Activation of parabrachial tachykinin 1 neurons counteracts some behaviors mediated by parabrachial calcitonin gene-related peptide neurons

JW Arthurs, JL Pauli, RD Palmiter - Neuroscience, 2023 - Elsevier
Many threats activate parabrachial neurons expressing calcitonin gene-related peptide
(CGRP PBN) which transmit alarm signals to forebrain regions. Most CGRP PBN neurons …

PACAP6-38 improves nitroglycerin-induced central sensitization by modulating synaptic plasticity at the trigeminal nucleus caudalis in a male rat model of chronic …

L Zhang, Y Zhou, L Yang, Y Wang, Z Xiao - The Journal of Headache and …, 2023 - Springer
Aims Chronic migraine (CM) is a common neurological disorder with complex pathogenesis.
Evidence suggests that pituitary adenylate cyclase-activating peptide (PACAP) induces …

[HTML][HTML] Neurokinin 1/3 receptor antagonists for menopausal women: A current systematic review and insights into the investigational non-hormonal therapy

F Hassan, A Saleem, SS Samuel, Z Sarfraz, A Sarfraz… - Medicine, 2023 - journals.lww.com
Background: Over 75% of menopausal women experience vasomotor symptoms (VMS),
such as night sweats and hot flashes. Despite the prevalence of these symptoms, there is …

Tachykinins and the potential causal factors for post-COVID-19 condition

SJ Janket, DD Fraser, AE Baird, F Tamimi… - The Lancet …, 2023 - thelancet.com
The most prevalent symptoms of post-COVID-19 condition are pulmonary dysfunction,
fatigue and muscle weakness, anxiety, anosmia, dysgeusia, headaches, difficulty in …

The Role of Glial Cells in Different Phases of Migraine: Lessons from Preclinical Studies

M Vila-Pueyo, O Gliga, VJ Gallardo… - International Journal of …, 2023 - mdpi.com
Migraine is a complex and debilitating neurological disease that affects 15% of the
population worldwide. It is defined by the presence of recurrent severe attacks of disabling …

Neuropeptides and the nodes of ranvier in cranial headaches

JCA Edvinsson, KA Haanes, L Edvinsson - Frontiers in Physiology, 2022 - frontiersin.org
The trigeminovascular system (TGV) comprise of the trigeminal ganglion with neurons and
satellite glial cells, with sensory unmyelinated C-fibers and myelinated Aδ-fibers picking up …

Expression of the Calcitonin Receptor-like Receptor (CALCRL) in Normal and Neoplastic Tissues

B Wende, ASL Beyer, N Ruhnke, D Kaemmerer… - International journal of …, 2023 - mdpi.com
Little information is available concerning protein expression of the calcitonin receptor-like
receptor (CALCRL) at the protein level. Here, we developed a rabbit monoclonal antibody …

MERTK in the rat trigeminal system: a potential novel target for cluster headache?

JCA Edvinsson, C Ran, FJ Olofsgård… - The Journal of …, 2024 - Springer
The trigeminal system is key to the pathophysiology of migraine and cluster headache, two
primary headache disorders that share many features. Recently, MER proto-oncogene …