Targeted drug delivery using nanobodies to deliver effective molecules to breast cancer cells: the most attractive application of nanobodies

MH Abdolvahab, P Karimi, N Mohajeri, M Abedini… - Cancer Cell …, 2024 - Springer
Targeted drug delivery is one of the attractive ways in which cancer treatment can
significantly reduce side effects. In the last two decades, the use of antibodies as a tool for …

Recent pre-clinical advancements in nuclear medicine: pioneering the path to a limitless future

W Echavidre, D Fagret, M Faraggi, V Picco… - Cancers, 2023 - mdpi.com
Simple Summary This review summarizes recent advances in the nuclear medicine
theranostic approach. It covers the repurposing of historical radiotracers for new indications …

Therapeutic potential of [177Lu]Lu-DOTAGA-FAPi dimers in metastatic breast cancer patients with limited treatment options: efficacy and safety assessment

MP Yadav, S Ballal, M Martin, F Roesch… - European Journal of …, 2024 - Springer
Purpose The upregulation of fibroblast activation protein (FAP) expression has been
observed in various cancers, including metastatic breast carcinoma, prompting research into …

Site-specific Radiohalogenation of a HER2-targeted single-domain antibody fragment using a Novel Residualizing Prosthetic agent

Y Feng, SM Sarrett, RL Meshaw… - Journal of medicinal …, 2022 - ACS Publications
Because of their rapid tumor accumulation and normal tissue clearance, single-domain
antibody fragments (sdAbs) are an attractive vehicle for developing radiotherapeutics …

Single-domain antibody theranostics on the horizon

W Wei, MH Younis, X Lan, J Liu… - Journal of Nuclear …, 2022 - Soc Nuclear Med
Single-domain antibody (sdAb) is among the most promising vectors for developing
molecular imaging tracers. Several sdAb tracers targeting human epidermal growth factor …

Effective treatment of human breast carcinoma xenografts with single-dose 211At-labeled anti-HER2 single-domain antibody fragment

Y Feng, R Meshaw, XG Zhao, S Jannetti… - Journal of Nuclear …, 2023 - Soc Nuclear Med
Single-domain antibody fragments (sdAbs) are attractive for targeted α-particle therapy,
particularly with 211At, because of their rapid accumulation in tumor and clearance from …

Promising Diagnostic and Therapeutic Approaches Based on VHHs for Cancer Management

Y Cong, N Devoogdt, P Lambin, LJ Dubois… - Cancers, 2024 - mdpi.com
Simple Summary With around 15 kD molecular weight, VHHs are considered the smallest
antigen-binding fragments. Based on their unique properties, VHHs have broad application …

Antibody engineering for nuclear imaging and radioimmunotherapy

C Rodriguez, S Delaney, SM Sarrett… - Journal of Nuclear …, 2022 - Soc Nuclear Med
Radiolabeled antibodies have become indispensable tools in nuclear medicine. However,
the natural roles of antibodies within the immune system mean that they have several …

Plant-derived single domain COVID-19 antibodies

AM Shen, OM Malekshah, N Pogrebnyak… - … Clinics and Research, 2023 - journals.lww.com
Data show a decrease in the risk of hospitalization and death from COVID-19. To date,
global vaccinations for SARS-CoV-2 protections are underway, but additional treatments are …

In vitro and in vivo study on the treatment of non-small cell lung cancer with radionuclide labeled PD-L1 nanobody

M Zhu, J Zhang, M Yang, H Zhang, T Xu, F Kan… - Journal of Cancer …, 2023 - Springer
Purpose Nanobodies have become promising carriers due to excellent in vivo properties.
Radiopharmaceutical therapy targeting programmed cell death ligand 1 (PD-L1) is an …