Targeted drug delivery using nanobodies to deliver effective molecules to breast cancer cells: the most attractive application of nanobodies
Targeted drug delivery is one of the attractive ways in which cancer treatment can
significantly reduce side effects. In the last two decades, the use of antibodies as a tool for …
significantly reduce side effects. In the last two decades, the use of antibodies as a tool for …
Recent pre-clinical advancements in nuclear medicine: pioneering the path to a limitless future
W Echavidre, D Fagret, M Faraggi, V Picco… - Cancers, 2023 - mdpi.com
Simple Summary This review summarizes recent advances in the nuclear medicine
theranostic approach. It covers the repurposing of historical radiotracers for new indications …
theranostic approach. It covers the repurposing of historical radiotracers for new indications …
Therapeutic potential of [177Lu]Lu-DOTAGA-FAPi dimers in metastatic breast cancer patients with limited treatment options: efficacy and safety assessment
MP Yadav, S Ballal, M Martin, F Roesch… - European Journal of …, 2024 - Springer
Purpose The upregulation of fibroblast activation protein (FAP) expression has been
observed in various cancers, including metastatic breast carcinoma, prompting research into …
observed in various cancers, including metastatic breast carcinoma, prompting research into …
Site-specific Radiohalogenation of a HER2-targeted single-domain antibody fragment using a Novel Residualizing Prosthetic agent
Y Feng, SM Sarrett, RL Meshaw… - Journal of medicinal …, 2022 - ACS Publications
Because of their rapid tumor accumulation and normal tissue clearance, single-domain
antibody fragments (sdAbs) are an attractive vehicle for developing radiotherapeutics …
antibody fragments (sdAbs) are an attractive vehicle for developing radiotherapeutics …
Single-domain antibody theranostics on the horizon
W Wei, MH Younis, X Lan, J Liu… - Journal of Nuclear …, 2022 - Soc Nuclear Med
Single-domain antibody (sdAb) is among the most promising vectors for developing
molecular imaging tracers. Several sdAb tracers targeting human epidermal growth factor …
molecular imaging tracers. Several sdAb tracers targeting human epidermal growth factor …
Effective treatment of human breast carcinoma xenografts with single-dose 211At-labeled anti-HER2 single-domain antibody fragment
Y Feng, R Meshaw, XG Zhao, S Jannetti… - Journal of Nuclear …, 2023 - Soc Nuclear Med
Single-domain antibody fragments (sdAbs) are attractive for targeted α-particle therapy,
particularly with 211At, because of their rapid accumulation in tumor and clearance from …
particularly with 211At, because of their rapid accumulation in tumor and clearance from …
Promising Diagnostic and Therapeutic Approaches Based on VHHs for Cancer Management
Simple Summary With around 15 kD molecular weight, VHHs are considered the smallest
antigen-binding fragments. Based on their unique properties, VHHs have broad application …
antigen-binding fragments. Based on their unique properties, VHHs have broad application …
Antibody engineering for nuclear imaging and radioimmunotherapy
C Rodriguez, S Delaney, SM Sarrett… - Journal of Nuclear …, 2022 - Soc Nuclear Med
Radiolabeled antibodies have become indispensable tools in nuclear medicine. However,
the natural roles of antibodies within the immune system mean that they have several …
the natural roles of antibodies within the immune system mean that they have several …
Plant-derived single domain COVID-19 antibodies
AM Shen, OM Malekshah, N Pogrebnyak… - … Clinics and Research, 2023 - journals.lww.com
Data show a decrease in the risk of hospitalization and death from COVID-19. To date,
global vaccinations for SARS-CoV-2 protections are underway, but additional treatments are …
global vaccinations for SARS-CoV-2 protections are underway, but additional treatments are …
In vitro and in vivo study on the treatment of non-small cell lung cancer with radionuclide labeled PD-L1 nanobody
M Zhu, J Zhang, M Yang, H Zhang, T Xu, F Kan… - Journal of Cancer …, 2023 - Springer
Purpose Nanobodies have become promising carriers due to excellent in vivo properties.
Radiopharmaceutical therapy targeting programmed cell death ligand 1 (PD-L1) is an …
Radiopharmaceutical therapy targeting programmed cell death ligand 1 (PD-L1) is an …