Arrow of time, entropy, and protein folding: Holistic view on biochirality

VV Dyakin, VN Uversky - International Journal of Molecular Sciences, 2022 - mdpi.com
Chirality is a universal phenomenon, embracing the space–time domains of non-organic
and organic nature. The biological time arrow, evident in the aging of proteins and …

Fundamental Cause of Bio-Chirality: Space-Time Symmetry—Concept Review

VV Dyakin - Symmetry, 2022 - mdpi.com
The search for fundamental determinants of bio-molecular chirality is a hot topic in biology,
clarifying the meaning of evolution and the enigma of life's origin. The question of origin may …

Exploring the aging process of cognitively healthy adults by analyzing cerebrospinal fluid metabolomics using liquid chromatography-tandem mass spectrometry

FC Liu, ML Cheng, CJ Lo, WC Hsu, G Lin, HT Lin - BMC geriatrics, 2023 - Springer
Background During biological aging, significant metabolic dysregulation in the central
nervous system may lead to cognitive decline and neurodegeneration. However, the …

Enigma of Pyramidal Neurons: Chirality-Centric View on Biological Evolution. Congruence to Molecular, Cellular, Physiological, Cognitive, and Psychological …

VV Dyakin, NV Dyakina-Fagnano - Symmetry, 2024 - mdpi.com
The mechanism of brain information processing unfolds within spatial and temporal domains
inherently linked to the concept of space–time symmetry. Biological evolution, beginning …

[HTML][HTML] Inhibitor PF-04691502 works as a senolytic to regulate cellular senescence

Z Fan, Y Tong, Z Yang, S Wang, T Huang… - Experimental …, 2024 - Elsevier
Aging is a gradual process of natural change that occurs after reaching sexual maturity. It is
also a known risk factor for many chronic diseases. Recent research has shown that …

Stem cells from human exfoliated deciduous teeth rejuvenate the liver in naturally aged mice by improving ribosomal and mitochondrial proteins

C Xing, Z Hang, W Guo, Y Li, R Shah, Y Zhao, Z Zeng… - Cytotherapy, 2023 - Elsevier
Background aims Aging is accompanied by a decline in cellular proteome homeostasis,
mitochondrial, and metabolic function. Mesenchymal stromal cell (MSC) therapies have …

Detection of genetic variation in bovine CRY1 gene and its associations with carcass traits

K Zhang, F Mi, X Li, Z Wang, F Jiang, E Song… - Animal …, 2023 - Taylor & Francis
The biological clock (also known as circadian clock) is closely related to growth and
development, metabolism, and diseases in animals. As a part of the circadian clock, the …

Enigma of Pyramidal Neurons: Congruence to Molecular, Cellular, Physiological, Cognitive and Psychological Function

VV Dyakin - 2023 - preprints.org
In bilaterians organism, the signaling of pyramidal neurons (PyrNs) is linked to the relative
(prevalent) molecular chirality and physiological, perceptual, cognitive, and psychological …

Are the mRNA vaccines inducing the Sanarelli-Shwartzman phenomenon?

RM Davidson, TR Winey - GSC Advanced Research and …, 2022 - gsconlinepress.com
Adverse events of myocarditis, pericarditis, and thrombosis, temporally associated with
mRNA vaccination (s) and/or mRNA vaccine boosters, have been reported during post …