Despite being highly preventable, cervical cancer is the fourth most common cancer and
cause of cancer death in women globally. In low‐income countries, cervical cancer is often …

Human papillomavirus (HPV) vaccines, which were introduced in many countries in the past
decade, have shown promising results in decreasing HPV infection and related diseases …

Advances in antiretroviral therapy (ART) have made it possible for persons with human
immunodeficiency virus (HIV) to live a near expected life span, without progressing to AIDS …

Background Robust age-specific estimates of anal human papillomavirus (HPV) and high-
grade squamous intraepithelial lesions (HSIL) in men can inform anal cancer prevention …

Background Vaccines have been demonstrated to protect against high-risk human
papillomavirus infection (HPV), including HPV-16/18, and cervical lesions among HIV …

Gay, bisexual, and other men who have sex with men (MSM) and transgender women,
particularly those who are living with HIV, are disproportionately affected by human …

Background Understanding the natural history of anal high-risk human papillomavirus
(hrHPV) infection is key for designing anal cancer prevention programs but has not been …

Simple Summary Head and neck cancers of the oropharyngeal subsite can be driven by the
human papillomavirus (HPV). In countries such as the United States, the incidence of HPV …

Purpose Anal intraepithelial neoplasia (AIN) is the accepted precursor of anal squamous
cell carcinoma (ASCC). There has long been a hypothesis that treating AIN may prevent …

This chapter provides an overview of anal cancer and contemporary approaches for anal
precancer detection, beginning with a discussion of the biology and natural history of anal …