Molecular diagnostics are revolutionising the clinical practice of infectious disease. Their
effects will be significant in acute-care settings where timely and accurate diagnostic tools …

Combinations of antiretroviral drugs have proven remarkably effective in controlling the
progression of HIV disease and prolonging survival, but these benefits can be compromised …

Background The T-20 vs. Optimized Regimen Only Study 1 (TORO 1) was a randomized,
open-label, phase 3 study of enfuvirtide (T-20), a human immunodeficiency virus type 1 (HIV …

To investigate the extent to which drug resistance mutations are missed by standard
genotyping methods, we analyzed the same plasma samples from 26 patients with …

SUMMARY HIV-1 DNA exists in nonintegrated linear and circular episomal forms and as
integrated proviruses. In patients with plasma viremia, most peripheral blood mononuclear …

The use of chemotherapy to suppress replication of the human immunodeficiency virus (HIV)
has transformed the face of AIDS in the developed world. Pronounced reductions in illness …

ObjectiveNew information warrants updated recommendations for the 4 central issues in
antiretroviral therapy: when to start, what drugs to start with, when to change, and what to …

Therapeutic success of anti-HIV therapies is limited by the development of drug resistant
viruses. These genetic variants display complex mutational patterns in their pol gene, which …

There are 16 approved human immunodeficiency virus type 1 (HIV-1) drugs belonging to
three mechanistic classes: protease inhibitors, nucleoside and nucleotide reverse …

Genotypic HIV drug resistance testing is routinely used to guide clinical decisions. While
genotyping methods can be standardized, a slow, labor-intensive, and subjective manual …