Highly active antiretroviral therapy (HAART), in which three or more drugs are given in
combination, has substantially improved the clinical management of HIV-1 infection. Still, the …

Background: Agents for the treatment of HIV-1-infected patients with resistance to current
antiretroviral (ART) drugs are needed. Methods: TMC114-C202 was a randomized, partially …

The failure of raltegravir (RAL) is generally associated with the selection of mutations at
integrase position Y143, Q148, or N155. However, a relatively high proportion of failures …

Our objective was to accurately predict, from complex mutation patterns, human
immunodeficiency virus type 1 resistance to the protease inhibitor lopinavir, by use of …

Limited access to HIV drug resistance testing in low-and middle-income countries impedes
clinical decision-making at the individual patient level. An efficient protocol to address this …

The virological response of multiple protease inhibitor-experienced, non-nucleoside reverse
transcriptase inhibitor-naive, HIV-1-infected subjects was examined with respect to baseline …

Objective To study the appearance of drug-induced mutations at low viraemia in treated HIV-
1-infected patients. Design and methods Fourteen patients, who received their first (n= 5) …

Background The evolution of drug-resistant viruses challenges the management of human
immunodeficiency virus (HIV) infections. Understanding this evolutionary process is …

Wild-type viruses from the ViroLogic phenotype-genotype database were evaluated to
determine the upper confidence limit of the drug susceptibility distributions, or “biological …

Background The optimal antiretroviral treatment for patients who have human
immunodeficiency virus (HIV) viremia despite treatment with nucleoside reverse …