Ischemic stroke is one of the significant causes of morbidity and mortality, affecting millions
of people across the globe. Cell injury in the infarct region is an inevitable consequence of …

Parkinson's disease (PD) is a chronic neurodegenerative condition which has the second
largest incidence rate among all other neurodegenerative disorders barring Alzheimer's …

Human neuroblastoma SH-SY5Y is a dopaminergic neuronal cell line which has been used
as an in vitro model for neurotoxicity experiments. Although the neuroblastoma is usually …

MicroRNAs (miRNAs) are implicated in both tissue differentiation and maintenance of tissue
identity. In most cases, however, the mechanisms underlying their regulation are not known …

Studies with animal models have suggested that reaction of glia, including microglia and
astrocytes, critically contributes to the development and maintenance of chronic pain …

Oxidative stress-induced cell damage is an important component of many diseases and
ageing. In eukaryotes, activation of JNK/p38 stress-activated protein kinase (SAPK) …

The detrimental effect of severe hypoxia (SH) on neurons can be mitigated by hypoxic
preconditioning (HPC), but the molecular mechanisms involved remain unclear, and an …

Reactive astrogliosis is an essential feature of astrocytic response to all forms of central
nervous system (CNS) injury and disease, which may benefit or harm surrounding neural …

Physiological stress can be defined as any external or internal condition that challenges the
homeostasis of a cell or an organism. It can be divided into three different aspects …

Traumatic brain injury (TBI) is a major cause of disability and death in patients who
experience a traumatic injury. Mitochondrial dysfunction is one of the main factors …