Effect of electrical stimulation on neural regeneration via the p38-RhoA and ERK1/2-Bcl-2 pathways in spinal cord-injured rats

MC Joo, CH Jang, JT Park, SW Choi, S Ro… - Neural regeneration …, 2018 - journals.lww.com
Although electrical stimulation is therapeutically applied for neural regeneration in patients,
it remains unclear how electrical stimulation exerts its effects at the molecular level on spinal …

The CORM ALF-186 mediates anti-apoptotic signaling via an activation of the p38 MAPK after ischemia and reperfusion injury in retinal ganglion cells

F Ulbrich, KB Kaufmann, A Meske, WA Lagrèze… - PLoS …, 2016 - journals.plos.org
Purpose Ischemia and reperfusion injury may induce apoptosis and lead to sustained tissue
damage and loss of function, especially in neuronal organs. While carbon monoxide is …

Identify the key active ingredients and pharmacological mechanisms of compound XiongShao capsule in treating diabetic peripheral neuropathy by network …

M Yu, X Song, W Yang, Z Li, X Ma… - … and Alternative Medicine, 2019 - Wiley Online Library
Compound XiongShao Capsule (CXSC), a traditional herb mixture, has shown significant
clinical efficacy against diabetic peripheral neuropathy (DPN). However, its multicomponent …

Hypoxia induces neurite outgrowth in PC12 cells that is mediated through adenosine A2A receptors

CM O'driscoll, AM Gorman - Neuroscience, 2005 - Elsevier
Development of the nervous system is a complex process, involving coordinated regulation
of diverse cellular processes including proliferation, differentiation and synaptogenesis …

Preliminary identification of key miRNAs, signaling pathways, and genes associated with Hirschsprung's disease by analysis of tissue microRNA expression profiles

ZG Gao, QJ Chen, M Shao, YZ Qian, LF Zhang… - World Journal of …, 2017 - Springer
Background Hirschsprung's disease (HSCR) is a congenital gut motility disorder of infants,
and if left untreated, it is fatal to the affected infants. This study aimed to identify key …

BMP/TGF‐β signaling as a modulator of neurodegeneration in ALS

K Russo, KA Wharton - Developmental Dynamics, 2022 - Wiley Online Library
This commentary focuses on the emerging intersection between BMP/TGF‐β signaling roles
in nervous system function and the amyotrophic lateral sclerosis (ALS) disease state. Future …

Stress kinase signaling in cancer: fact or fiction?

U Rennefahrt, M Janakiraman, R Öllinger, J Troppmair - Cancer letters, 2005 - Elsevier
Cancer results from genetic alterations in intracellular signaling pathways, which normally
orchestrate the execution of developmental programs and the organismic response to …

Identification of Op18/stathmin as a potential target of ASK1‐p38 MAP kinase cascade

K Mizumura, K Takeda, S Hashimoto… - Journal of cellular …, 2006 - Wiley Online Library
Apoptosis signal‐regulating kinase 1 (ASK1) is a mitogen‐activated protein (MAP) kinase
kinase kinase that activates the JNK and p38 MAP kinase cascades and has a broad range …

Dipeptide mimetic of BDNF ameliorates motor dysfunction and striatal apoptosis in 6-OHDA-induced Parkinson's rat model: Considering Akt and MAPKs signaling

B Firouzan, F Iravanpour, F Abbaszadeh… - Behavioural Brain …, 2023 - Elsevier
Parkinson's disease (PD) is a progressive and debilitating neurodegenerative disorder
associated with motor and non-motor complaints. Dysregulation of neurotrophic factors and …

Expression and activation of mitogen-activated protein kinases in the optic nerve head in a rat model of ocular hypertension

T Mammone, G Chidlow, RJ Casson… - Molecular and Cellular …, 2018 - Elsevier
Background Glaucoma is a leading cause of irreversible blindness manifesting as an age-
related, progressive optic neuropathy with associated retinal ganglion cell (RGC) loss …