Ever since the first isolation of Exaltolide 1 (Figure 1) in 1927 by Kerschbaum, 1 interest in
macrocyclic lactones, defined as lactones with more than 8 atoms in the ring, has been …

Umpolung-based strategies play a significant role in organic synthesis. Particularly
important are 1, 3-dithiane linchpins, which serve as convenient acyl anion equivalents. The …

Marine organisms, particularly sponge invertebrates and associated bacteria, are
enormously rich sources of structurally diverse secondary metabolites with unique molecular …

The normal reactivity of a carbonyl compound (I) is as an a 1-reagent (II) and the temporary
reversal of the characteristic pattern of reactivity of a functional group is described by the …

1. INTRODUCTION Ever since the first isolation of Exaltolide 1 (Figure 1) in 1927 by
Kerschbaum, 1 interest in macrocyclic lactones, defined as lactones with more than 8 atoms …

As synthetic targets have grown more complex, protection/deprotection protocols have
assumed prominent roles in synthetic organic chemistry. 1–3 The ability to efficiently protect …

Marine organisms produce a fascinating range of structurally diverse secondary metabolites,
which often possess unusual and sometimes unexpected biological activities. This structural …

An alkoxide-catalyzed directed diboration of alkenyl alcohols is described. This reaction
occurs in a stereoselective fashion and is demonstrated with cyclic and acyclic homoallylic …

Multicomponent union tactics in which three or more fragments are rapidly connected are
highly prized in the construction of architecturally complex natural products. Anion Relay …

A new anion relay enabled [3+ 3]-annulation of active methylene isocyanides and
conjugated ene-yne-ketones was developed for the efficient and straightforward synthesis of …