P16INK4A (also known as P16 and MTS1), a protein consisting exclusively of four ankyrin
repeats, is recognized as a tumor suppressor mainly because of the prevalence of genetic …

DNA methylation is an epigenetic modification involved in both normal developmental
processes and disease states through the modulation of gene expression and the …

Inactivation of the tumor suppressor genes tumor protein p53 (TP53) and cyclin-dependent
kinase inhibitor 2A (CDKN2A) occurs early during gastroesophageal junction (GEJ) …

Objective An international meeting was organised to develop consensus on (1) the
landmarks to define the gastro-oesophageal junction (GOJ),(2) the occurrence and …

Squamous cell carcinoma (SCC) is an epithelial malignancy involving many anatomical
sites and is the most common cancer capable of metastatic spread. Development of early …

Over recent decades we have witnessed a shift in the anatomical distribution of gastric
cancer (GC), which increasingly originates from the proximal stomach near the junction with …

Patients with Barrett's esophagus (BE) are at increased risk of developing esophageal
adenocarcinoma (EAC). Clinical neoplastic progression risk factors, such as age and the …

Background Somatic genetic CDKN2A, TP53, and DNA content abnormalities are common
in many human cancers and their precursors, including esophageal adenocarcinoma (EA) …

Advances in deep genomic sequencing have identified a spectrum of cancer-specific
passenger and driver aberrations. Clones with driver anomalies are believed to be positively …

Neoplastic progression is an evolutionary process characterized by genomic instability and
waves of clonal expansions carrying genetic and epigenetic lesions to fixation (100% of the …