Recent advances in carboxymethyl chitosan-based materials for biomedical applications

Y Geng, H Xue, Z Zhang, AC Panayi, S Knoedler… - Carbohydrate …, 2023 - Elsevier
Chitosan (CS) and its derivatives have been applied extensively in the biomedical field
owing to advantageous characteristics including biodegradability, biocompatibility …

Progress in alternative strategies to combat antimicrobial resistance: Focus on antibiotics

J Murugaiyan, PA Kumar, GS Rao, K Iskandar… - Antibiotics, 2022 - mdpi.com
Antibiotic resistance, and, in a broader perspective, antimicrobial resistance (AMR),
continues to evolve and spread beyond all boundaries. As a result, infectious diseases have …

Fighting antibiotic resistance—strategies and (pre) clinical developments to find new antibacterials

S Walesch, J Birkelbach, G Jézéquel, FPJ Haeckl… - EMBO …, 2023 - embopress.org
Antibacterial resistance is one of the greatest threats to human health. The development of
new therapeutics against bacterial pathogens has slowed drastically since the approvals of …

[HTML][HTML] A deep learning approach to antibiotic discovery

JM Stokes, K Yang, K Swanson, W Jin, A Cubillos-Ruiz… - Cell, 2020 - cell.com
Due to the rapid emergence of antibiotic-resistant bacteria, there is a growing need to
discover new antibiotics. To address this challenge, we trained a deep neural network …

The global preclinical antibacterial pipeline

U Theuretzbacher, K Outterson, A Engel… - Nature Reviews …, 2020 - nature.com
Antibacterial resistance is a great concern and requires global action. A critical question is
whether enough new antibacterial drugs are being discovered and developed. A review of …

Drug combinations: a strategy to extend the life of antibiotics in the 21st century

M Tyers, GD Wright - Nature Reviews Microbiology, 2019 - nature.com
Antimicrobial resistance threatens a resurgence of life-threatening bacterial infections and
the potential demise of many aspects of modern medicine. Despite intensive drug discovery …

Efficient exploration of terpenoid biosynthetic gene clusters in filamentous fungi

Y Yuan, S Cheng, G Bian, P Yan, Z Ma, W Dai… - Nature Catalysis, 2022 - nature.com
Terpenoids, critical components of human medicine, are the largest family of natural
products. Fungi are an important source of terpenoids, but many of the corresponding …

Futuristic non-antibiotic therapies to combat antibiotic resistance: A review

M Kumar, DK Sarma, S Shubham, M Kumawat… - Frontiers in …, 2021 - frontiersin.org
The looming problem of resistance to antibiotics in microorganisms is a global health
concern. The drug-resistant microorganisms originating from anthropogenic sources and …

Antibiotic discovery: where have we come from, where do we go?

B Ribeiro da Cunha, LP Fonseca, CRC Calado - Antibiotics, 2019 - mdpi.com
Given the increase in antibiotic-resistant bacteria, alongside the alarmingly low rate of newly
approved antibiotics for clinical usage, we are on the verge of not having effective treatments …

Nature is the best source of anticancer drugs: Indexing natural products for their anticancer bioactivity

A Rayan, J Raiyn, M Falah - PloS one, 2017 - journals.plos.org
Cancer is considered one of the primary diseases that cause morbidity and mortality in
millions of people worldwide and due to its prevalence, there is undoubtedly an unmet need …