Chronic pain is a major source of morbidity for which there are limited effective treatments.
Palmitoylethanolamide (PEA), a naturally occurring fatty acid amide, has demonstrated utility …

Palmitoylethanolamide (PEA) stands out among endogenous lipid mediators for its
neuroprotective, anti-inflammatory, and analgesic functions. PEA belonging to the N …

Central post-stroke pain (CPSP) and associated depression remain poorly understood and
pharmacological treatments are unsatisfactory. Recently, microglia activation was suggested …

Long COVID is a recognized post-viral syndrome characterized by neurological, somatic
and neuropsychiatric symptoms that might last for long time after SARS-CoV-2 infection. An …

The signaling pathways associated with lipid metabolism contribute to the pathophysiology
of autism spectrum disorder (ASD) and provide insights for devising new therapeutic …

Cannabinoid type 2 receptor (CB2R), belonging to the endocannabinoid system, is
overexpressed in pathologies characterized by inflammation, and its activation counteracts …

Palmitoylethanolamide (PEA), an endogenous lipid mediator, is emerging as a promising
pharmacological agent in multiple neurodegenerative disorders for its anti-inflammatory and …

Current epidemiological data estimate that one in five people suffers from chronic pain with
considerable impairment of health-related quality of life. The pharmacological treatment is …

Abstract Purpose of Review Almost half of people diagnosed with diabetes mellitus will
develop painful diabetic neuropathy (PDN), a condition greatly impacting quality of life with …

Introduction The endocannabinoid (eCB) system disruption has been suggested to underpin
the development of psychosis, fueling the search for novel, better-tolerated antipsychotic …