The mechanism of action of cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) remains
surprisingly unclear. Regulatory T (Treg) cells can use CTLA-4 to elicit suppression; …

Cancer treatment by immune checkpoint blockade (ICB) can bring long-lasting clinical
benefits, but only a fraction of patients respond to treatment. To predict ICB response, we …

Regulatory T cells (Tregs) maintain immune equilibrium by suppressing immune responses
through various multistep contact dependent and independent mechanisms. Cellular …

CD4+ T regulatory cells (Treg) are central to immune homeostasis, their phenotypic
heterogeneity reflecting the diverse environments and target cells that they regulate. To …

Both conventional T (Tconv) cells and regulatory T (Treg) cells are activated through ligation
of the T cell receptor (TCR) complex, leading to the induction of the transcription factor NF …

Much of the knowledge about cell differentiation and function in the immune system has
come from studies in mice, but the relevance to human immunology, diseases, and therapy …

Cytotoxic T-lymphocyte-associated antigen-4 (CTLA-4) is an essential regulator of T-cell
responses, and its absence precipitates lethal T-cell hyperactivity. However, whether CTLA …

A combination of transcription factors, enhancers, and epigenetic marks determines the
expression of the key transcription factor FoxP3 in regulatory T cells (Tregs). Adding an …

FoxP3 conditions the transcriptional signature and functional facets of regulatory T cells
(Treg cells). Its mechanism of action, whether as an activator or a repressor, has remained …

RORγ+ and Helios+ Treg cells in the colon are phenotypically and functionally distinct, but
their origins and relationships are poorly understood. In monocolonized and normal mice …