Parkinson disease (PD) is the second-most common neurodegenerative disease. The
characteristic pathology of progressive dopaminergic neuronal loss in people with PD is …

Balancing cell survival and cell death is fundamental to development and homeostasis. Cell
death is regulated by multiple interconnected signaling pathways and molecular …

When cells undergo necrotic cell death in either physiological or pathophysiological settings
in vivo, they release highly immunogenic intracellular molecules and organelles into the …

Necroptosis is a regulated, nonapoptotic form of cell death initiated by receptor-interacting
protein kinase-3 (RIPK3) and mixed lineage kinase domain-like (MLKL) proteins. It is …

Ferroptosis, a novel form of regulated cell death, is characterized by oxidative injury from
iron accumulation and lipid peroxidation. In a natural product library screening for ferroptosis …

Several insults cause the inner mitochondrial membrane to abruptly lose osmotic
homeostasis, hence initiating a regulated variant of cell death known as 'mitochondrial …

The early history of vitamin E from its discovery by Herbert M. Evans and Katharine JS
Bishop in 1922 up to its chemical synthesis by Paul Karrer and coworkers in 1938 and the …

Autophagy serves a dichotomous role in cancer and recent advances have helped delineate
the appropriate settings where inhibiting or promoting autophagy may confer therapeutic …

Programmed cell death (PCD) is an evolutionarily conserved contributor to nervous system
development. In the vertebrate peripheral nervous system, PCD is the basis of the …

Precisely identifying the type of programmed cell death is one of the key questions in
contemporary biomedical research. We developed a straightforward approach allowing …