Targeting biomolecular condensation and protein aggregation against cancer
Biomolecular condensates, membrane-less entities arising from liquid–liquid phase
separation, hold dichotomous roles in health and disease. Alongside their physiological …
separation, hold dichotomous roles in health and disease. Alongside their physiological …
Protein misfolding and amyloid nucleation through liquid–liquid phase separation
Liquid–liquid phase separation (LLPS) is an emerging phenomenon in cell physiology and
diseases. The weak multivalent interaction prerequisite for LLPS is believed to be facilitated …
diseases. The weak multivalent interaction prerequisite for LLPS is believed to be facilitated …
The liquid-to-solid transition of FUS is promoted by the condensate surface
A wide range of macromolecules can undergo phase separation, forming biomolecular
condensates in living cells. These membraneless organelles are typically highly dynamic …
condensates in living cells. These membraneless organelles are typically highly dynamic …
Liquid-droplet-mediated ATP-triggered amyloidogenic pathway of insulin-derived chimeric peptides: unraveling the microscopic and molecular processes
Disease-associated progression of protein dysfunction is typically determined by an
interplay of transition pathways leading to liquid–liquid phase separation (LLPS) and …
interplay of transition pathways leading to liquid–liquid phase separation (LLPS) and …
Distinct effects of familial Parkinson's disease-associated mutations on α-synuclein phase separation and amyloid aggregation
B Xu, F Fan, Y Liu, Y Liu, L Zhou, H Yu - Biomolecules, 2023 - mdpi.com
The Lewy bodies and Lewy neurites are key pathological hallmarks of Parkinson's disease
(PD). Single-point mutations associated with familial PD cause α-synuclein (α-Syn) …
(PD). Single-point mutations associated with familial PD cause α-synuclein (α-Syn) …
From a Droplet to a Fibril and from a Fibril to a Droplet: Intertwined Transition Pathways in Highly Dynamic Enzyme-Modulated Peptide-Adenosine Triphosphate …
Many cellular coassemblies of proteins and polynucleotides facilitate liquid–liquid phase
separation (LLPS) and the subsequent self-assembly of disease-associated amyloid fibrils …
separation (LLPS) and the subsequent self-assembly of disease-associated amyloid fibrils …
Time-dependent material properties of aging biomolecular condensates from different viscoelasticity measurements in molecular dynamics simulations
AR Tejedor, R Collepardo-Guevara… - The Journal of …, 2023 - ACS Publications
Biomolecular condensates are important contributors to the internal organization of the cell
material. While initially described as liquid-like droplets, the term biomolecular condensates …
material. While initially described as liquid-like droplets, the term biomolecular condensates …
[PDF][PDF] 耗散粒子动力学方法在生物学领域的应用与研究进展: 从蛋白质结构到细胞力学
唐梓涵， 李学进， 李德昌 - 科学通报, 2023 - researchgate.net
摘要耗散粒子动力学(dissipative particle dynamics, DPD) 是近年发展起来的一种介观尺度的
数值模拟方法, 是研究软物质和复杂流体动力学行为的一种重要手段. 这种新型介观模拟方法 …
数值模拟方法, 是研究软物质和复杂流体动力学行为的一种重要手段. 这种新型介观模拟方法 …
Modulation of α-synuclein aggregation amid diverse environmental perturbation
Intrinsically disordered protein α-synuclein (αS) is implicated in Parkinson's disease due to
its aberrant aggregation propensity. In a bid to identify the traits of its aggregation, here we …
its aberrant aggregation propensity. In a bid to identify the traits of its aggregation, here we …
Orchestrating vesicular and nonvesicular membrane dynamics by intrinsically disordered proteins
SJ Sigrist, V Haucke - EMBO reports, 2023 - embopress.org
Compartmentalization by membranes is a common feature of eukaryotic cells and serves to
spatiotemporally confine biochemical reactions to control physiology. Membrane‐bound …
spatiotemporally confine biochemical reactions to control physiology. Membrane‐bound …