The complement system plays a key role in pathogen immunosurveillance and tissue
homeostasis. However, subversion of its tight regulatory control can fuel a vicious cycle of …

Although new activation and regulatory mechanisms are still being identified, the basic
architecture of the complement system has been known for decades. Two major roles of …

Background Excessive activation of immune responses in coronavirus disease 2019
(COVID-19) is considered to be related to disease severity, complications, and mortality rate …

Complement activation is associated with common rheumatic diseases such as systemic
lupus erythematosus (SLE), rheumatoid arthritis (RA) and systemic vasculitis. Evidence …

We recently observed that dysregulation of the complement system may be involved in the
pathogenesis of hematopoietic stem cell transplantation–associated thrombotic …

The importance of the complement system in clinical medicine has become evident during
the last decades and complement therapeutics has now reached the clinic. Thus, there is an …

Complement system aberrations have been identified as pathophysiological mechanisms in
a number of diseases and pathological conditions either directly or indirectly. Examples of …

Background Antibody-mediated rejection (AMR) is a severe form of rejection, mediated
primarily by antibody-dependent complement (C) activation. C1 inhibitor (C1-INH, Berinert) …

Background The complement system is an essential component of our innate defense and
plays a vital role in the pathogenesis of many diseases. Assessment of complement …

This guideline aims to describe the complement system and the functions of the constituent
pathways, with particular focus on primary immunodeficiencies (PIDs) and their diagnosis …