PTEN is a phosphatase which metabolises PIP 3, the lipid product of PI 3-Kinase, directly
opposing the activation of the oncogenic PI3K/AKT/mTOR signalling network. Accordingly …

The phosphatidylinositol-3-kinase (PI3K)/Akt and the mammalian target of rapamycin
(mTOR) signaling pathways are two pathways crucial to many aspects of cell growth and …

The development of the TMTpro-16plex series expanded the breadth of commercial isobaric
tagging reagents by nearly 50% over classic TMT-11plex. In addition to the described …

The transcription factor nuclear factor erythroid-derived 2-like 2 (NRF2) participates in the
activation of the antioxidant cytoprotective pathway and other important physiological …

Colorectal cancer (CRC) is the third most common type of cancer worldwide and a leading
cause of cancer death. Surgery represents the mainstay of treatment in early cases but often …

Regulation of the PI-3 kinase (PI3K)/Akt signalling pathway is essential for maintaining the
integrity of fundamental cellular processes, cell growth, survival, death and metabolism, and …

Akt kinase, a member of AGC kinases, is important in many cellular functions including
proliferation, migration, cell growth and metabolism. There are three known Akt isoforms …

Energy metabolism is significantly reprogrammed in many human cancers, and these
alterations confer many advantages to cancer cells, including the promotion of biosynthesis …

Background. Intrahepatic cholangiocarcinoma (ICC) is a subtype of primary liver cancer that
is rarely curable by surgery and is rapidly increasing in incidence. Relapsed ICC has a poor …

Insulin resistance is common in individuals with obesity or type 2 diabetes (T2D), in which
circulating insulin levels are frequently increased. Recent epidemiological and clinical …