TDP-43 is the primary or secondary pathological hallmark of neurodegenerative diseases,
such as amyotrophic lateral sclerosis, half of frontotemporal dementia cases, and limbic age …

Importance Biomarkers are lacking that can discriminate frontotemporal lobar degeneration
(FTLD) associated with tau (FTLD-tau) or TDP-43 (FTLD-TDP). Objective To test whether …

Frontotemporal dementia (FTD) is one of the most common neurodegenerative diseases,
encompassing a myriad of different, clinically distinct subtypes which all target the …

Background: The differential diagnosis of frontotemporal dementia (FTD) is still a
challenging task due to its symptomatic overlap with other neurological diseases and the …

Background Lack of early molecular biomarkers in sporadic behavioral variants of
frontotemporal dementia (bvFTD) and its clinical overlap with primary psychiatric disorders …

Tauopathies are a heterogeneous group of neurodegenerative disorders that are clinically
and pathologically distinct from Alzheimer's disease (AD) having tau inclusions in neurons …

Background and objectives Early-stage behavioural variant frontotemporal dementia
(bvFTD) is often misdiagnosed, highlighting the need for new diagnostic instruments. Based …

Genome-wide association studies have successfully identified many genetic risk loci for
dementia, but exact biological mechanisms through which genetic risk factors contribute to …

The clinical overlap of frontotemporal dementia and primary psychiatric diseases hampers
diagnostic distinction, leading to frequent misdiagnosis and diagnostic delay. Neurofilament …

The pathophysiological mechanisms driving disease progression of frontotemporal lobar
degeneration (FTLD) and corresponding biomarkers are not fully understood. We leveraged …