This review is confined to sensors that use fluorescence to transmit biochemical information.
Fluorescence is, by far, the most frequently exploited phenomenon for chemical sensors and …

Several theories have been postulated, trying to explain why and how living organisms age.
Despite some controversies and still huge open questions, a growing body of evidence …

The brain requires over one-fifth of the total body oxygen demand for normal functioning. At
high altitude (HA), the lower atmospheric oxygen pressure inevitably challenges the brain …

We previously found that luteolin (Lut) appeared to improve the contractility of
cardiomyocytes during ischemia/reperfusion in rats. The enhancement was associated with …

Oxidative post-translational modifications (oxPTM) of receptors, enzymes, ion channels and
transcription factors play an important role in cell signaling. oxPTMs are a key way in which …

Background: SERCA [sarco (endo) plasmic reticulum calcium ATPase] is regulated by
oxidative posttranslational modifications at cysteine 674 (C674). Because sarcoplasmic …

The endoplasmic reticulum (ER) has emerged as a source of hydrogen peroxide (H2O2)
and a hub for peroxide-based signaling events. Here we outline cellular sources of ER …

Discordant myocardial growth and angiogenesis can explain left ventricular (LV)
hypertrophy progressing toward heart failure with aging. Sirtuin 1 expression declines with …

Mouse hindlimb ischemia has been widely used as a model to study peripheral artery
disease. Genetic modulation of the enzymatic source of oxidants or components of the …

We report a signaling pathway linking two fundamental functions of the ER, oxidative protein
folding, and intracellular calcium regulation. Cells sense ER oxidative protein folding …