Nrf2 signaling links ER oxidative protein folding and calcium homeostasis in health and disease
V Granatiero, C Konrad, K Bredvik… - Life science …, 2019 - life-science-alliance.org
We report a signaling pathway linking two fundamental functions of the ER, oxidative protein
folding, and intracellular calcium regulation. Cells sense ER oxidative protein folding …
folding, and intracellular calcium regulation. Cells sense ER oxidative protein folding …
Sarco/Endoplasmic Reticulum Ca2+ ATPase 2 Activator Ameliorates Endothelial Dysfunction; Insulin Resistance in Diabetic Mice
T Kimura, K Kagami, A Sato, A Osaki, K Ito, S Horii… - Cells, 2022 - mdpi.com
Background: Sarco/endoplasmic reticulum Ca2+-ATPase2 (SERCA2) is impaired in various
organs in animal models of diabetes. The purpose of this study was to test the effects of an …
organs in animal models of diabetes. The purpose of this study was to test the effects of an …
Substitution of SERCA2 Cys674 aggravates cardiac fibrosis by promoting the transformation of cardiac fibroblasts to cardiac myofibroblasts
X Huang, X Lin, L Wang, Y Xie, Y Que, S Li, P Hu… - Biochemical …, 2022 - Elsevier
Abstract Sarcoplasmic/endoplasmic reticulum Ca 2+ ATPase 2 (SERCA2) is vital to maintain
intracellular calcium homeostasis, and its redox Cys 674 (C674) is the key to regulating …
intracellular calcium homeostasis, and its redox Cys 674 (C674) is the key to regulating …
[HTML][HTML] Early Life Stress Influences Oxidative Stress Enzyme Activities in Liver, Heart, Kidney, Suprarenal Glands, and Pancreas in Male and Female Rat Pups
B Fenton Navarro, AA Casimiro Aguayo… - Antioxidants, 2024 - mdpi.com
Early life stress (ELS) is a risk factor for the development of chronic diseases resulting from
functional alterations of organs in the cardiorespiratory and renal systems. This work studied …
functional alterations of organs in the cardiorespiratory and renal systems. This work studied …
Redox Regulation of Ischemic Angiogenesis–Another Aspect of Reactive Oxygen Species–
Y Watanabe, RA Cohen, R Matsui - Circulation Journal, 2016 - jstage.jst.go.jp
Antioxidants are expected to improve cardiovascular disease (CVD) by eliminating oxidative
stress, but clinical trials have not shown promising results in chronic CVD. Animal studies …
stress, but clinical trials have not shown promising results in chronic CVD. Animal studies …
Redox control of angiogenesis
K Schröder - Antioxidants & redox signaling, 2019 - liebertpub.com
Significance: Angiogenesis is the formation of new vessels that sprout from existing vessels.
This process is highly complex and requires a coordinated shift of the endothelial phenotype …
This process is highly complex and requires a coordinated shift of the endothelial phenotype …
SERCA2 dysfunction triggers hypertension by interrupting mitochondrial homeostasis and provoking oxidative stress
Y Wang, M Wang, H Su, J Song, M Ren, P Hu… - Free Radical Biology …, 2024 - Elsevier
Background and aim Sarcoplasmic/endoplasmic reticulum Ca 2+ ATPase 2 (SERCA2) is
critical in maintaining Ca 2+ homeostasis. The cysteine 674 (C674) is the key redox …
critical in maintaining Ca 2+ homeostasis. The cysteine 674 (C674) is the key redox …
Inactivation of Cys674 in SERCA2 increases BP by inducing endoplasmic reticulum stress and soluble epoxide hydrolase
G Liu, F Wu, X Jiang, Y Que, Z Qin, P Hu… - British Journal of …, 2020 - Wiley Online Library
Background and Purpose The kidney is essential in regulating sodium homeostasis and BP.
The irreversible oxidation of Cys674 (C674) in the sarcoplasmic/endoplasmic reticulum …
The irreversible oxidation of Cys674 (C674) in the sarcoplasmic/endoplasmic reticulum …
Roles of the mitochondrial Na+-Ca2+ exchanger, NCLX, in B lymphocyte chemotaxis
B Kim, A Takeuchi, M Hikida, S Matsuoka - Scientific reports, 2016 - nature.com
Lymphocyte chemotaxis plays important roles in immunological reactions, although the
mechanism of its regulation is still unclear. We found that the cytosolic Na+-dependent …
mechanism of its regulation is still unclear. We found that the cytosolic Na+-dependent …
Inactivation of cysteine 674 in the SERCA2 accelerates experimental aortic aneurysm
Y Que, X Shu, L Wang, P Hu, S Wang, R Xiong… - Journal of Molecular and …, 2020 - Elsevier
Abstract Sarcoplasmic/endoplasmic reticulum Ca 2+ ATPase 2 (SERCA2) is vital to maintain
intracellular calcium homeostasis. SERCA2 cysteine 674 (C674) is highly conservative and …
intracellular calcium homeostasis. SERCA2 cysteine 674 (C674) is highly conservative and …