Systemic lupus erythematosus (SLE) is an autoimmune multisystem disease featured by an
increased cardiovascular risk that may lead to premature patient's death. It has been …

Pulmonary hypertension (PH) is a life-threatening disease characterized by pulmonary
vascular remodeling, in which hyperproliferation of pulmonary artery smooth muscle cells …

Abstract Sarcoplasmic/endoplasmic reticulum Ca 2+ ATPase 2 (SERCA2) is vital to maintain
intracellular calcium homeostasis. SERCA2 cysteine 674 (C674) is highly conservative and …

Ischemia is a complex phenomenon modulated by the concerted action of several cell types.
We have identified that sarcoplasmic/endoplasmic reticulum Ca 2+ ATPase 2 (SERCA 2) …

The endothelium produces and responds to reactive oxygen and nitrogen species (RONS),
providing important redox regulation to the cardiovascular system in physiology and …

Background and Purpose Inactivation of Cys674 (C674) in the sarcoplasmic/endoplasmic
reticulum Ca2+ ATPase 2 (SERCA2) causes intracellular Ca2+ accumulation, which …

Mitochondria are critical organelles in eukaryotes that efficiently generate adenosine 5′-
triphosphate (ATP) for various biological activities, and any defect in the process of ATP …

The angiogenic function of endothelial cells (ECs) is very important to tissues and organs
that suffer from hypoxic injury. Exploring the role of endoplasmic reticulum (ER) Ca 2+ …

To observe whether downhill running can lead to DNA damage in skeletal muscle cells and
changes in mitochondrial membrane permeability and to explore whether the DNA damage …

Diabetic retinopathy is a multifactorial microvascular complication, and its pathogenesis
hasn't been fully elucidated. The irreversible oxidation of cysteine 674 (C674) in the …