Detection of microbial DNA is an evolutionarily conserved mechanism that alerts the host
immune system to mount a defense response to microbial infections. However, this detection …

Dissection of the genetic basis of Aicardi–Goutières syndrome has highlighted a
fundamental link between nucleic acid metabolism, innate immune sensors and type I …

Inhibition of cytosolic DNA sensing represents a strategy that tumor cells use for immune
evasion, but the underlying mechanisms are unclear. Here we have shown that CD47-signal …

Although the replicative life cycle of HIV within CD4 T cells is understood in molecular detail,
less is known about how this human retrovirus promotes the loss of CD4 T lymphocytes. It is …

During acute HIV-1 infection, viral pathogen-associated molecular patterns are recognized
by pathogen-recognition receptors (PRRs) of infected cells, which triggers a signaling …

Interactions between the host and viruses during the course of their co-evolution have not
only shaped cellular function and the immune system, but also the counter measures …

Abstract Structure-specific endonucleases (SSEs) have key roles in DNA replication,
recombination and repair, and emerging roles in transcription. These enzymes have …

HIV-1 has evolved mechanisms to evade host cell immune responses and persist for lifelong
infection. Latent cellular reservoirs are responsible for this persistence of HIV-1 despite the …

The FERM domain protein Merlin, encoded by the NF2 tumor suppressor gene, regulates
cell proliferation in response to adhesive signaling. The growth inhibitory function of Merlin …

The progressive depletion of CD4 T cells underlies clinical progression to AIDS in untreated
HIV-infected subjects. Most dying CD4 T cells correspond to resting nonpermissive cells …