[HTML][HTML] Therapeutic application of quercetin in aging-related diseases: SIRT1 as a potential mechanism

Z Cui, X Zhao, FK Amevor, X Du, Y Wang, D Li… - Frontiers in …, 2022 - frontiersin.org
Quercetin, a naturally non-toxic flavonoid within the safe dose range with antioxidant, anti-
apoptotic and anti-inflammatory properties, plays an important role in the treatment of aging …

[HTML][HTML] Oxidative stress and inflammation in osteoarthritis pathogenesis: Role of polyphenols

MY Ansari, N Ahmad, TM Haqqi - Biomedicine & pharmacotherapy, 2020 - Elsevier
Osteoarthritis (OA) is the most prevalent joint degenerative disease leading to irreversible
structural and functional changes in the joint and is a major cause of disability and reduced …

[HTML][HTML] Nrf2-mediated anti-inflammatory polarization of macrophages as therapeutic targets for osteoarthritis

L Wang, C He - Frontiers in Immunology, 2022 - frontiersin.org
Macrophages are the most abundant immune cells within the synovial joints, and also the
main innate immune effector cells triggering the initial inflammatory responses in the …

[HTML][HTML] Osteoarthritis year in review 2020: biology

MHJ van den Bosch - Osteoarthritis and Cartilage, 2021 - Elsevier
This year in review about osteoarthritis biology highlights a selection of articles published
between the 2019 and 2020 Osteoarthritis Research Society International (OARSI) World …

Immunopolarization-regulated 3D printed-electrospun fibrous scaffolds for bone regeneration

X Liu, M Chen, J Luo, H Zhao, X Zhou, Q Gu, H Yang… - Biomaterials, 2021 - Elsevier
Abstract Three-dimension (3D)-printed bioscaffolds are precise and personalized for bone
regeneration. However, customized 3D scaffolds may activate the immune response in vivo …

Quercetin‐loaded ceria nanocomposite potentiate dual‐directional immunoregulation via macrophage polarization against periodontal inflammation

Y Wang, C Li, Y Wan, M Qi, Q Chen, Y Sun, X Sun… - Small, 2021 - Wiley Online Library
Macrophage polarization toward M1 phenotype (pro‐inflammation) is closely associated
with the destructive phase of periodontal inflammation. Nanoceria is verified to inhibit M1 …

[HTML][HTML] Therapeutic and pharmacological efficacy of selective Indian medicinal plants–a review

M Prasathkumar, S Anisha, C Dhrisya, R Becky… - Phytomedicine Plus, 2021 - Elsevier
Globally, traditional herbal medicines have played a vital role in health systems, and are
used to treat various acute and chronic conditions without or minimal toxic effect. Herbal …

Senescence in osteoarthritis: from mechanism to potential treatment

Y Liu, Z Zhang, T Li, H Xu, H Zhang - Arthritis Research & Therapy, 2022 - Springer
Osteoarthritis (OA) is an age-related cartilage degenerative disease, and chondrocyte
senescence has been extensively studied in recent years. Increased numbers of senescent …

[HTML][HTML] Curcumin exerts chondroprotective effects against osteoarthritis by promoting AMPK/PINK1/Parkin-mediated mitophagy

Z Jin, B Chang, Y Wei, Y Yang, H Zhang, J Liu… - Biomedicine & …, 2022 - Elsevier
Osteoarthritis (OA), a chronic degenerative disease with heterogeneous properties, is
difficult to cure due to its complex pathogenesis. Curcumin possesses excellent anti …

Failure of cartilage regeneration: emerging hypotheses and related therapeutic strategies

S Muthu, JV Korpershoek, EJ Novais… - Nature Reviews …, 2023 - nature.com
Osteoarthritis (OA) is a disabling condition that affects billions of people worldwide and
places a considerable burden on patients and on society owing to its prevalence and …