Ubiquitination is a posttranslational modification of proteins that significantly affects protein
stability and function. The specificity of substrate recognition is determined by ubiquitin E3 …

The dysregulation of Notch signaling is found in many cancers and is closely related to
cancer progression. As an important Notch receptor, abnormal Notch4 expression affects …

Evolutionarily conserved DDB1‐and CUL4‐associated factor 13 (DCAF13) is a recently
discovered substrate receptor for the cullin RING‐finger ubiquitin ligase 4 (CRL4) E3 …

DDB1 and CUL4 associated factor 13 (DCAF13) is a substrate receptor in the CUL4‐DDB1
E3 ligase, and its expression is associated with the prognosis of certain cancers. In the …

Purpose The underlying mechanisms of hepatocellular carcinoma (HCC) have not been
fully investigated, and effective biomarkers for HCC are still needed to be explored …

Until recently, Deltex (DTX) proteins have been considered putative E3 ligases, based on
the presence of an E3 RING domain in their protein coding sequence. The human DTX …

Purpose Triple-negative breast cancer (TNBC) represents an aggressive subtype of breast
cancer characteristic of high recurrence rate and poor prognosis. According to previous …

DCAF13 is a substrate recognition protein in the ubiquitin‐proteasome system with
oncogenic effects in several malignant tumors. However, it is unclear that the relationship …

Nuclear-localized epidermal growth factor receptor (EGFR) highly correlates with the
malignant progression and may be a promising therapeutic target for breast cancer …

Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related deaths
globally. Tumor metastasis is one of the major causes of high mortality of HCC. Identifying …