Minocycline hydrochloride (MH), a semi-synthetic tetracycline derivative, is a clinically
available antibiotic and anti-inflammatory drug that also exhibits potent neuroprotective …

Chronic pain is nowadays considered not only the mainstay symptom of rheumatic diseases
but also “a disease itself.” Pain is a multidimensional phenomenon, and in inflammatory …

Spinal microglia are widely recognized as activated by and contributing to the generation
and maintenance of inflammatory and nerve injury related chronic pain; whereas the role of …

While glial activation is an integral part of pain pathogenesis, the existence of a causal
relationship between glia and pain processing has yet to be demonstrated in vivo. Here, we …

Oxaliplatin is a third-generation platinum-based chemotherapeutic drug. Although its
efficacy against colorectal cancer is well known, peripheral neuropathy that develops during …

Neurotoxicity is a main side effect of the anticancer drug oxaliplatin. The development of a
neuropathic syndrome impairs quality of life and potentially results in chemotherapy dose …

Curcumin has been shown to possess strong anti-inflammatory activity in many diseases. It
has been demonstrated that the janus kinase 2 (JAK2)-signal transducer and activator of …

Oxaliplatin, unlike other platinum anticancer agents, has only mild toxic effects on the
hematopoietic, urinary and gastrointestinal systems. Its dose-limiting side effect is …

Mirror-image pain is characterized by mechanical hypersensitivity on the uninjured mirror-
image side. Recent reports favor central mechanisms, but whether peripheral mechanisms …

BACKGROUND: Electroacupuncture (EA) has therapeutic effects on neuropathic pain
induced by nerve injury; however, the underlying mechanisms remain unclear. In this study …