Repurposing ibudilast to mitigate Alzheimer's disease by targeting inflammation
G Oliveros, CH Wallace, O Chaudry, Q Liu, Y Qiu, L Xie… - Brain, 2023 - academic.oup.com
Alzheimer's disease is a multifactorial disease that exhibits cognitive deficits, neuronal loss,
amyloid plaques, neurofibrillary tangles and neuroinflammation in the brain. Hence, a multi …
amyloid plaques, neurofibrillary tangles and neuroinflammation in the brain. Hence, a multi …
Machine learning-based q-RASAR approach for the in silico identification of novel multi-target inhibitors against Alzheimer's disease
In the present research, we present the application of a novel approach, termed the Machine
Learning (ML)-Based q-RASAR (quantitative read-across structure-activity relationship) …
Learning (ML)-Based q-RASAR (quantitative read-across structure-activity relationship) …
Diagnosis of Alzheimer's disease by joining dual attention CNN and MLP based on structural MRIs, clinical and genetic data
YR Qiang, SW Zhang, JN Li, Y Li, QY Zhou… - Artificial Intelligence in …, 2023 - Elsevier
Alzheimer's disease (AD) is an irreversible central nervous degenerative disease, while mild
cognitive impairment (MCI) is a precursor state of AD. Accurate early diagnosis of AD is …
cognitive impairment (MCI) is a precursor state of AD. Accurate early diagnosis of AD is …
Indication of neurodegenerative cascade initiation by amyloid-like aggregate-forming EBV proteins and peptide in Alzheimer's disease
The neurotropic potential of the Epstein-Barr virus (EBV) was demonstrated quite recently;
however, the mechanistic details are yet to be explored. Therefore, the effects of EBV …
however, the mechanistic details are yet to be explored. Therefore, the effects of EBV …
Comprehensive understanding of Hispanic caregivers: Focus on innovative methods and validations
Alzheimer's disease (AD) and Alzheimer's disease-related disorders (ADRD) are late-onset,
age-related progressive neurodegenerative disorders, characterized by memory loss and …
age-related progressive neurodegenerative disorders, characterized by memory loss and …
Effect of Terahertz Waves on the Structure of the Aβ42 Monomer, Dimer, and Protofibril: Insights from Molecular Dynamics Simulations
C Chen, ZS Yan, YQ Ma, HM Ding - ACS Chemical Neuroscience, 2023 - ACS Publications
Amyloid-β (Aβ) and its assemblies play important roles in the pathogenesis of Alzheimer's
disease (AD). Recent studies conducted by experimental and computational researchers …
disease (AD). Recent studies conducted by experimental and computational researchers …
Sex difference in brain functional connectivity of hippocampus in Alzheimer's disease
J Williamson, SA James, P Mukli, A Yabluchanskiy… - GeroScience, 2024 - Springer
Abstract Alzheimer's disease (AD), affecting nearly 6.5 million people, is the fifth leading
cause of death in individuals 65 years or older in the USA. Prior research has shown that AD …
cause of death in individuals 65 years or older in the USA. Prior research has shown that AD …
A novel transgenic mouse line with hippocampus-dominant and inducible expression of truncated human tau
Y Gao, Y Wang, H Lei, Z Xu, S Li, H Yu, J Xie… - Translational …, 2023 - Springer
Background Intraneuronal accumulation of hyperphosphorylated tau is a defining hallmark
of Alzheimer's disease (AD). However, mouse models imitating AD-exclusive neuronal tau …
of Alzheimer's disease (AD). However, mouse models imitating AD-exclusive neuronal tau …
CoQ10 and Mitochondrial Dysfunction in Alzheimer's Disease
Z Fišar, J Hroudová - Antioxidants, 2024 - mdpi.com
The progress in understanding the pathogenesis and treatment of Alzheimer's disease (AD)
is based on the recognition of the primary causes of the disease, which can be deduced …
is based on the recognition of the primary causes of the disease, which can be deduced …
[HTML][HTML] The need for systems thinking to advance Alzheimer's disease research
Despite extensive research efforts to mechanistically understand late-onset Alzheimer's
disease (LOAD) and other complex mental health disorders, curative treatments remain …
disease (LOAD) and other complex mental health disorders, curative treatments remain …