During each cell duplication, the entirety of the genomic DNA in every cell must be
accurately and quickly copied. Given the short time available for the chore, the requirement …

In eukaryotes, genomic DNA is tightly wrapped in chromatin. The nucleosome is a basic unit
of chromatin, but acts as a barrier to transcription. To overcome this impediment, the RNA …

Proper maintenance of epigenetic information after replication is dependent on the rapid
assembly and maturation of chromatin. Chromatin Assembly Complex 1 (CAF-1) is a …

Abstract Aims In this study, Mrhst4, encoding a member of NAD+-dependent histone
deacetylase (HDAC), was deleted to evaluate its regulation on the production of Monascus …

Post‐translational modifications of histones are essential in the regulation of chromatin
structure and function. Among these modifications, lysine acetylation is one of the most …

Chromatin features are thought to have a role in the epigenetic transmission of transcription
states from one cell generation to the next. It is unclear how chromatin structure survives …

Background Type II germ cell tumors (GCT) are the most common solid cancers in males of
age 15 to 35 years. Treatment of these tumors includes cisplatin-based therapy achieving …

Eukaryotic cells maintain an optimal level of mRNAs through unknown mechanisms that
balance RNA synthesis and degradation. We found that inactivation of the RNA exosome …

Eukaryotic cells rely upon dynamic, multifaceted regulation at each step of RNA biogenesis
to maintain mRNA pools and ensure normal protein synthesis. Studies in budding yeast …

Background The quality of gene annotation determines the interpretation of results obtained
in transcriptomic studies. The growing number of genome sequence information calls for …