Worldwide increases in life expectancy have been paralleled by a greater prevalence of
chronic and age-associated disorders, particularly of the cardiovascular, neural and …

Studies using high-resolution genome-wide approaches have recently reported that
genomic and epigenomic alterations frequently accumulate in human pluripotent cells …

The state of a cell is defined by the genes it transcribes and the epigenetic landscape that
regulates their expression. Pluripotent cells have markedly different epigenetic signatures …

Genome-wide expression analysis using next generation sequencing (RNA-Seq) provides
an opportunity for in-depth molecular profiling of fundamental biological processes, such as …

Rett syndrome (RTT) is one of the most prevalent female neurodevelopmental disorders that
cause severe mental retardation. Mutations in methyl CpG binding protein 2 (MeCP2) are …

The systematic generation of neurons from patients with neurological disorders can provide
important insights into disease pathology, progression and mechanism. This review will …

Human pluripotent stem cells (hPSCs) are being increasingly utilized worldwide in
investigating human development, and modeling and discovering therapies for a wide range …

Sex differences are present in brain morphology, sex hormones, aging processes and
immune responses. These differences need to be considered for proper modelling of …

Fragile X-associated tremor/ataxia syndrome (FXTAS) is a leading monogenic
neurodegenerative disorder affecting premutation carriers of the fragile X (FMR1) gene. To …

Human pluripotent stem cells (hPSCs) hold a central role in studying human development,
in disease modeling and in regenerative medicine. These cells not only acquire genetic …