Lipid metabolism, in particular the synthesis of fatty acids (FAs), is an essential cellular
process that converts nutrients into metabolic intermediates for membrane biosynthesis …

The metabolic properties of cancer cells diverge significantly from those of normal cells.
Energy production in cancer cells is abnormally dependent on aerobic glycolysis. In addition …

Targeting altered tumour metabolism is an emerging therapeutic strategy for cancer
treatment. The metabolic reprogramming that accompanies the development of malignancy …

Introduction: Ten years ago, we put forward the metabolo-oncogenic nature of fatty acid
synthase (FASN) in breast cancer. Since the conception of this hypothesis, which provided a …

There is a renewed interest in the ultimate role of fatty acid synthase (FASN)—a key
lipogenic enzyme catalysing the terminal steps in the de novo biogenesis of fatty acids—in …

An accelerated de novo lipogenesis (DNL) flux is a common characteristic of cancer cells
required to sustain a high proliferation rate. The DNL enzyme fatty acid synthase (FASN) is …

Therapies that target tumor metabolism represent a new horizon in anticancer therapies. In
particular, cancer cells are dependent on the generation of lipids, which are essential for cell …

Resistance of cancer cells to chemotherapy is the first cause of cancer-associated death.
Thus, new strategies to deal with the evasion of drug response and to improve clinical …

Cancer is a daunting global problem confronting the world's population. The most frequent
therapeutic approaches include surgery, chemotherapy, radiotherapy, and more recently …

There is growing evidence that metabolic alterations play an important role in cancer
development and progression. The metabolism of cancer cells is reprogrammed in order to …